IkB-alpha Products

Description

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB (1). Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified (1). One of the first gene induced following NF-kB activation is IkBa.

Bioinformatics

Entrez	18035 Mouse 25493 Rat 4792 Human
Uniprot	AAH04983 Human NP_065390 Human P25963 Human
Product By Gene ID	4792
Alternate Names	alpha I-kappa-B-alpha IkappaBalphaNF-kappa-B inhibitor alpha IKBAikB-alpha IkB-alpha MAD3 MAD-3 Major histocompatibility complex enhancer-binding protein MAD3 NFKBI nuclear factor of kappa light chain gene enhancer in B-cells nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

Research Areas for IkB-alpha

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology
Diabetes Research
DNA Repair
Nucleotide Excision Repair
Phospho-Specific
Signal Transduction

Related IkB-alpha Blog Posts

Check out the latest blog posts on IkB-alpha.

The effects of curcumin on IKB Alpha and the NFkB signaling pathway The IKK complex, or inhibitor of NFkB kinase, is composed of IKK alpha and IKK beta.  These kinases are at the core of the NFkB signaling cascade.  The NFkB family is made up of transcription factors that are kept inactive in the cytoplasm through...    Read more.

Sample collection from mammalian culture cells for kinomic analysis By Jamshed Arslan Pharm.D., PhD.IntroductionKinome describes kinases, and kinomics refers to the kinase signaling. Studying the effects of reagent (exogenously applied growth factor or inhibitor) on kinase activit...    Read more.

Inhibitor kappa B-alpha (IkappaB-alpha) The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is ess...    Read more.

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