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Nuclear LC3: Why is it there and what is it doing?

hHpr1-p84-Thoc1 Antibody

By Christina Towers, PhD.

Tags: 
Autophagy
LC3
p62/SQSTM1
Lysosome
autophagosome
ATG
ATG7
ATG8 and ATG4B
LC3A

CAR-T Cell Therapy: Refining the Approach in Solid Tumors

CAR-T Cell Killing

By Jacqueline Carrico, BS, MD Candidate

Tags: 
Cancer
Tumor
Lymphocytes
CD4
CD8
immunology
PKA
Cytokines

Killing two birds with one stone: Treating inflammation and cancer by inhibiting prolyl-4-hydroxylase-1

Bi-directional Cross-talk Between HIF1-alpha and NF kappa B

By Jamshed Arslan Pharm.D.

Tags: 
Hypoxia
HIF
PHD
Inflammation
Cancer
p53
NF-kB
Apoptosis
RelA/NFkB p65

Getting Physical: Link between Lipid Metabolism and Hypoxia Target Genes

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

Tags: 
HIF
HIF-1alpha
p-VHL
FASN
Hypoxia
Cancer
VEGF

Autophagy inhibition in pediatrics: One physician-scientist’s brave decision

Autophagy Pathway, Novus Biologicals, macroautophagy induction, autophagosome maturation, microautophagy, autolysosome, elongation

By Christina Towers, PhD.

Tags: 
Autophagy
Cancer
ATG
Tumor
Immune System
immunity
T-Cells
LC3B
p62/SQSTM1
Lysosome
Neuroscience
Brain
neurodegeneration
Chloroquine
vemurafenib
oncology
Christina Towers

Cleaner gone bad: Autophagy regulates motor neuron loss in spinal muscular atrophy

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

Tags: 
Autophagy
Cancer
ATG
Tumor
Immune System
immunity
T-Cells
LC3B
p62/SQSTM1
Apoptosis
inhibition
neuromuscular
spinal muscular atrophy
rapamycin
Jamshed Arslan
Western blot

Autophagy in the Tumor Microenvironment

Biogenesis Molecular

By Christina Towers, PhD.

Tags: 
Autophagy
Cancer
ATG
Tumor
Immune System
immunity
T-Cells

Cross-talk between proteasome degradation and lysosomal degradation

Autophagy Pathway

By Christina Towers, PhD.

Tags: 
Autophagy
Proteasome
p62/SQSTM1
LC3
autophagosome
Lysosome
PolyQ
neurodegeneration
LC3B

Application Focus: New Methods for iPSC Differentiation, Inducing a Mammary Fate

Lactalbumin Antibody Immunohistochemistry Paraffin NBP1-87715

Discovery of the Key to Pluripotency

Tags: 
Organoids
Stem Cells
OCT4
Sox2
c-Myc
KLF4
Collagen
Insulin
FGF
HGF
Prolactin
pTHrP
Pluripotency
iPSC
Breast Cancer

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma

TGF-B Pathway

By Jamshed Arslan Pharm.D.

Tags: 
HIF-1 alpha
TGF-beta
SMAD
NANOG
OCT4
Sox2
Cancer
Hypoxia
Wnt
beta-catenin
Stem Cells

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