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Hypoxia

Hypoxia-Dependent CAR Stabilizing Construct in T cells Improves Solid Tumor Targeting and Efficacy

Banner image showing a chimeric antigen receptor (CAR) T cell.

By Victoria Osinski, PhD

Tags: 
Cancer
Chimeric Antigen Receptor
CAR-T
Hypoxia
immunology
Immunotherapy
Oxygen
T Cells
Tumor
Tumor Microenvironment
EGFR
ErbB2/Her2
ErbB3/Her3
ErbB4/Her4
HIF-1 alpha
Victoria Osinski

Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment

Banner image showing cancer cells in hypoxic conditions.

By Hunter Martinez

Tags: 
Adaptive Immunity
Hypoxia
immunology
metabolism
Mitochondria
Oxygen
ROS
T Cells
T cell exhaustion
T cell receptor
Tumor Microenvironment
BLIMP1/PRDM1
CD8
HIF-1 alpha
IFN-gamma
LAG-3
NFAT
NGFI-B alpha/Nur77/NR4A1
PD-1
PGC1 alpha
TIGIT
TNF-alpha
Hunter Martinez

Transcriptional co-activators Yap1 and Taz control growth and development

Schematic of Hippo signaling pathway highlighting Yap and Taz proteins.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Apoptosis
Cancer
Cell Proliferation
Embryonic Stem Cells
Hypoxia
Pluripotency
Stem Cells
Hippo
YAP1
TAZ
TAZ/WWTR1
TEF1
TEAD4
MCM3
MCM4
MCM6
MCM10
OCT1
Sox2
cIAP-1/HIAP-2
Survivin
Bcl-2
Mcl-1
cdx2
gata-3
HNF-4 alpha/NR2A1
Jagged 1
MYF-5
MYF6
Myogenin
Prox1
N-cadherin
Vimentin
SNAIL
Slug
TAK1
MDH2
HIF-1 alpha
Jamshed Arslan

Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness

Immunohistochemical staining of paraffin-embedded human breast carcinoma with rabbit polyclonal Oct4 antibody.


By Jamshed Arslan, Pharm D, PhD

Tags: 
Breast Cancer
Cancer
Hypoxia
KLF4
NANOG
OCT4
Sox2
S100A10
Annexin A2
HIF-1 alpha
HIF-2 alpha/EPAS1
SPT6
KDM6A
Pluripotency
chemotherapy
Jamshed Arslan

Detecting HIF alpha and beyond: Best controls for hypoxia Western blot analysis

Analysis of HIF-1 alpha expression in whole cell lysates from HeLa cells in culture treated or untreated with cobalt chloride and independent antibody validation where two different antibodies to HIF-1 alpha were used for immunoprecipitation and detection.

By Rosa Moreno, PhD.

Tags: 
Hypoxia
Cancer
Western blot
HIF-1-alpha
HIF-2-alpha-epas1
ARNT-HIF-1-beta
erythropoietin-epo
egln1-phd2
von-hippel-lindau
kat3b-p300
CREB
cobalt chloride
CoCl2
carbonic-anhydrase-ix-ca9
alpha-tubulin
igfbp-1
igf-ii-igf2
GLUT1
lactate-dehydrogenase-a-ldha
VEGF
lrp-1

Negative feedback regulation of EPAS1 gene in non-small cell lung cancer through DNA methyltransferases

HIF-1 alpha expression in human lung tissue, IHC

By Jamshed Arslan Pharm.D.

Tags: 
Cancer
Epigenetics
Hypoxia
HIF-1 alpha
HIF-2 alpha
HIF-1 beta
EPAS1
ChIP
DNMT1
DNMT3a
Dnmt3b
Non-Small Cell Lung Cancer

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling

Collagen-I expression in rat colon tissue IHC

By Jamshed Arslan Pharm.D.

Tags: 
Epigenetics
Cancer
Tumor
Hypoxia
TGF-beta
HIF-1 alpha
Bambi
SOX4
VIM
MMP9
Ki67
IPO-38
N-cadherin
Collagen-1
Snai1
Acta2
Twist1
Fibronectin
EMT

Adenosine Inhibits T cell Tumor Infiltration: KCa3.1, a New Anticancer Target

CD8 alpha antibody, ICC

By Yoskaly Lazo-Fernandez, PhD

Tags: 
Cancer
T Cells
Immunotherapy
immunology
Hypoxia
Adenosine A2a R
CD39/ENTPD1
5'-Nucleotidase/CD73

Mitochondrial ATPase inhibitory factor 1 (IF1) provides an explanation of cancer growth in anoxia or pseudo-anoxia

ATPase inhibitor factor 1 antibody ICC

By Jamshed Arslan Pharm.D.

Tags: 
ATPase inhibitor factor 1
ATP synthase C mature
Hypoxia
Cancer

Killing two birds with one stone: Treating inflammation and cancer by inhibiting prolyl-4-hydroxylase-1

Bi-directional Cross-talk Between HIF1-alpha and NF kappa B

By Jamshed Arslan Pharm.D.

Tags: 
Hypoxia
HIF
PHD
Inflammation
Cancer
p53
NF-kB
Apoptosis
RelA/NFkB p65

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