Hypoxia

The HIF family are heterodimeric, oxygen-sensitive transcription factors comprising an alpha and beta subunit which are normally dissociated in normoxic conditions. Our antibody catalog contains products targeting all the Hypoxia Inducible Factor isoforms which have been identified in mammalian cells. These include HIF-2 alpha antibody reagents targeting both the entire protein and specific epitopes.

The hypoxia inducible factors are a family of heterodimeric transcription factors which are activated in response to lowered oxygen levels, or hypoxia. Although it may seem that HIF-1 alpha receives all the attention, other HIF antibodies, such as the HIF-2 alpha and HIF-1 beta antibody, are frequently used in clinical research as well.

The Hypoxia Inducible Factors (HIFs) are a family of mammalian transcription factors which are expressed in response to low cellular oxygen concentrations (hypoxia). Three human hypoxia inducible factors have been identified, HIF-1, HIF-2 and HIF-3, each having an alpha and a beta subunit.

Hypoxia-Inducible Factor-1 (HIF-1) is a highly conserved heterodimeric transcription factor. Novus' antibody catalogue contains an extensive range of both HIF-1 alpha and HIF-1 beta, useful for hypoxia, angiogenesis, cancer and many other areas of research.

COX IV isoform 1 is a nuclear-encoded polypeptide chain of the Cytochrome C Oxidase enzyme, located on the mitochondrial inner membrane. Owing to its widespread distribution in human and mammalian tissues, COX IV antibodies are widely used as loading controls for immunological assays.

Ischemic cardiovascular disease is the leading cause of death for both men and women in the US and most other industrialized countries. Most commonly caused by atherosclerosis of the coronary arteries, ischemic cardiovascular disease is characterized by a reduced blood supply to the heart, leading to low oxygen, glucose, and pH levels.

The Hypoxia-inducible Factor 1 (HIF1) protein is a heterodimeric transcription factor which plays an important role in mammalian oxygen homeostasis in conditions of hypoxia, or low oxygen concentration. HIF-1 alpha antibody reagents are widely used in disease research, as hypoxia is known to contribute to many diseases including cancer, pulmonary hypertension and congenital heart disease. We at Novus Biologicals are one of the leading antibody suppliers of HIF-1 products.

We at Novus Biologicals have a large HIF-1 (Hypoxia Inducible Factor-1) antibody catalog, with twenty HIF-1 beta antibody products specifically targeted to the beta subunit of HIF-1, a heterodimer which is known to contribute to many human diseases arising from changes in oxygen homeostasis.

We at Novus Biologicals have a large antibody database devoted to signalling pathways. These underpin every area of molecular biological research, including cancer. Among our cell signalling antibodies is one targeted to DLL4 (Delta-like protein 4). DLL4 is a homologue of the Drosophila delta gene, known to encode DSL-domain ligands on the Notch signaling pathway.

Stem cell marker antibodies are used to identify and isolate stem cells in vitro. Whereas adult stem cells can only differentiate into one cell type, embryonic stem cells (ESCs) have the unique ability to differentiate into a large variety. Stem cells can be genetically manipulated into specific cell lines, and researchers have recently developed a promising new method of producing ESC-like cell lines from adult stem cells.