The Hypoxia Inducible Factors (HIFs) are a family of mammalian transcription factors which are expressed in response to low cellular oxygen concentrations (hypoxia). Three human hypoxia inducible factors have been identified, HIF-1, HIF-2 and HIF-3, each having an alpha and a beta subunit. Our antibody catalog at Novus Biologicals includes a full range of HIF products, including useful HIF-1 alpha antibody packs containing multiple different samples. The Hypoxia Inducible Factor antibody catalog is widely used in disease research, as hypoxia is a contributing factor in the pathogenesis of many diseases, including kidney disease. Hypoxia is also a common complication following renal allograft, or transplant surgery, resulting in necrosis and organ rejection. -Western%20Blot-NB100-105-img0005.jpg "Western Blot: HIF-1 alpha Antibody (H1alpha67)")
The kidney has a unique arrangement of preglomerular and postglomerular blood vessels, allowing shunt diffusion to take place. However, this means that despite an adequate supply of oxygenated blood to the renal system, oxygen tension remains low. This increases the risk of hypoxia, which is a recognized factor in both acute renal injury and chronic kidney disease. Using the HIF-1 alpha antibody, and other hypoxia products in our antibody catalog, researchers have shown that oxygen deprivation induces changes to regulatory pathways, with a profound effect on gene expression. The HIF transcription factors are activated in both chronic and acute renal disease, and play a crucial role in protecting the cell from hypoxic effects. Chronic allograft nephropathy (CAN) is a common cause of kidney failure following transplant surgery. Recent HIF-1 alpha antibody research has suggested prolonged hypoxic and ischemic states resulting from surgery cause upregulation of HIF-1 alpha, resulting in TGF-beta1 release and the development of CAN. Novus Biologicals offers HIF-1 alpha reagents for your research needs including:
