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Novel Approaches to Improve Efficacy and Safety of CAR-T Therapy

CAR-T Therapy

By Jacqueline Carrico, BS, MD Candidate

Tags: 
Caspase-9
NOTCH
Cancer
immunology
CAR-T
Tumor

Targeting Success in CAR-T Therapy for Solid Tumors

CAR-T poster

By Jacqueline Carrico, BS, MD Candidate

Tags: 
ErbB2/Her2
EGFR
EGFRvIII
IL-13 R alpha 2
Cancer
Tumor
Mesothelin

Mitochondrial ATPase inhibitory factor 1 (IF1) provides an explanation of cancer growth in anoxia or pseudo-anoxia

ATPase inhibitor factor 1 antibody ICC

By Jamshed Arslan Pharm.D.

Tags: 
ATPase inhibitor factor 1
ATP synthase C mature
Hypoxia
Cancer

Nuclear LC3: Why is it there and what is it doing?

hHpr1-p84-Thoc1 Antibody

By Christina Towers, PhD.

Tags: 
Autophagy
LC3
p62/SQSTM1
Lysosome
autophagosome
ATG
ATG7
ATG8 and ATG4B
LC3A

CAR-T Cell Therapy: Refining the Approach in Solid Tumors

CAR-T Cell Killing

By Jacqueline Carrico, BS, MD Candidate

Tags: 
Cancer
Tumor
Lymphocytes
CD4
CD8
immunology
PKA
Cytokines

Killing two birds with one stone: Treating inflammation and cancer by inhibiting prolyl-4-hydroxylase-1

Bi-directional Cross-talk Between HIF1-alpha and NF kappa B

By Jamshed Arslan Pharm.D.

Tags: 
Hypoxia
HIF
PHD
Inflammation
Cancer
p53
NF-kB
Apoptosis
RelA/NFkB p65

Getting Physical: Link between Lipid Metabolism and Hypoxia Target Genes

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

Tags: 
HIF
HIF-1alpha
p-VHL
FASN
Hypoxia
Cancer
VEGF

Autophagy inhibition in pediatrics: One physician-scientist’s brave decision

Autophagy Pathway, Novus Biologicals, macroautophagy induction, autophagosome maturation, microautophagy, autolysosome, elongation

By Christina Towers, PhD.

Tags: 
Autophagy
Cancer
ATG
Tumor
Immune System
immunity
T-Cells
LC3B
p62/SQSTM1
Lysosome
Neuroscience
Brain
neurodegeneration
Chloroquine
vemurafenib
oncology
Christina Towers

Cleaner gone bad: Autophagy regulates motor neuron loss in spinal muscular atrophy

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

Tags: 
Autophagy
Cancer
ATG
Tumor
Immune System
immunity
T-Cells
LC3B
p62/SQSTM1
Apoptosis
inhibition
neuromuscular
spinal muscular atrophy
rapamycin
Jamshed Arslan
Western blot

Autophagy in the Tumor Microenvironment

Biogenesis Molecular

By Christina Towers, PhD.

Tags: 
Autophagy
Cancer
ATG
Tumor
Immune System
immunity
T-Cells

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