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Cancer

Chromatin reader domains of DNMT-targeting protein, UHRF1, are responsible for cancerous DNA hypermethylation

Expression of DNMT2 in human colon tissue shows cytoplasmic and nuclear staining in glandular cells, IHC

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Cancer
Cancer Research
Epigenetics
Immunohistochemistry
Western blot
uhrf1
DNMT3a
fibulin-2
jdp2
latexin
prostasin-prss8
icam-4
Jamshed Arslan

Stemness is responsible for onset and metastasis of colorectal cancer

beta-Catenin expression in mouse colon, IHC

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Cancer
Cancer Research
Metastasis
CD133
CD166
CD44
beta-catenin
ALDH1
EphB2
LGR5
CXCR4
EpCAM/TROP1
cdx2
cytokeratin-20
Vimentin
Jamshed Arslan

Identifying tumoral and stromal transcriptomes that underlie tumor plasticity and stromal neuroinflammatory response in brain metastasis

AIF-1/Iba-1 expression in mouse brain, IHC

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Cancer
Neuroscience
Metastasis
Neuroinflammation
Inflammation
immunology
akap5
ephrin-b3
chl-1-L1cam-2
L1CAM
ncam-1-cd56
il-1-alpha-il-1f1
il-1-beta-il-1f2
c1qb
GFAP
CD68
ncf1
cytochrome-b245-alpha
ccl8-mcp-2
tgf-beta-1
aif-1-iba1
Jamshed Arslan

Toll-like receptor 2 activation contributes to oral squamous cell carcinoma development and miRNA-mediated drug resistance

Nuclear Factor kappa B (NFkB) signaling pathway poster, Novus Biologicals

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
immunology
Toll-Like Receptors
TLRs
TLR2
TLR1
TLR6
Pam3CSK4
NFk-B
CARD10
Jamshed Arslan

Success of combined IL-10 and IL-12 therapy in colon cancer depends on IFN-gamma and gut barrier integrity

IL10 receptor alpha expression in human colon carcinoma, IHC

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Cancer
Colorectal Cancer
Colon Cancer
Immunotherapy
immunology
T helper
Cytotoxic T cells
IL-10
IL-12
IFN-gamma
IL-10 R alpha
CD4
CD8
IL-17
Th17
ROR gamma t
Jamshed Arslan

Animal Models to Study Autophagy

Autophagy Signaling Pathway, Novus Biologicals, macroautophagy induction, elongation, microautophagy, autophagosome maturation, autolysosome

By Christina Towers, PhD

Tags: 
ULK1
ATG13
rb1cc11
beclin-1
AMBRA1
ATG14
vps14/pik3r4
VPS34
ATG9A
ATG7
Atg10
ATG12
ATG5
ATG4B
Atg3
LC3B
p62-sqstm1
Autophagy
autophagosome
Christina Towers
mCherry
GFP
Zebrafish
Animal models

Best Methods to Induce and Inhibit Autophagy Pharmacologically

VPS35 expression in endosomes and lysosomes of human U-2 OS cells, ICC

By Christina Towers, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3B
Bafilomycin
Chloroquine
Lysosome
Western blot
Beclin 1
VPS34
ULK1
ATG4B
mTOR
autophagy induction
autophagy inhibition
Christina Towers
Cancer
rapamycin
Autophagic flux

mTOR Signaling and the Tumor Microenvironment

mTOR signaling pathway poster

By Yoskaly Lazo-Fernandez, PhD

Tags: 
TOR/mTOR
mTORC1
mTORC2
mTOR
TME
PI3K
HIF-1 alpha
S6K1
Akt
PKC
SGK3
FoxO1/3
CD4
CD8
HIF-1
VEGF
HIF-1 beta

Negative feedback regulation of EPAS1 gene in non-small cell lung cancer through DNA methyltransferases

HIF-1 alpha expression in human lung tissue, IHC

By Jamshed Arslan Pharm.D.

Tags: 
Cancer
Epigenetics
Hypoxia
HIF-1 alpha
HIF-2 alpha
HIF-1 beta
EPAS1
ChIP
DNMT1
DNMT3a
Dnmt3b
Non-Small Cell Lung Cancer

Nickel induces migratory and invasive phenotype in human epithelial cells by epigenetically activating ZEB1

Epigenetic mechanisms Novus Biologicals

By Jamshed Arslan Pharm.D.

Tags: 
Cancer
Cancer Research
Epigenetics
Histones
ZEB1
EMT
Cadherin
claudin-1
Fibronectin
histone-h3
ChIP

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