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Unlocking the Potential of Biosimilars in Immuno-Oncology

Purple and blue antibodies with clear glass vial in the middle on a purple-blue background.

By Jennifer Jones, M.S.

Tags: 
Biosimilar
Biosimilar Antibody
Cancer
Cancer Immunotherapy
Immuno-oncology
Adalimumab
Atezolizumab
Bevacizumab
Nivolumab
Pembrolizumab
rituximab
trastuzumab
CD20
CD30/TNFRSF8
CD52
CTLA-4
ErbB2/Her2
PD-1
PD-L1
TNF-alpha
VEGF
Jennifer Jones

NPC1: A Potential Target For Triple-Negative Breast Cancer

Immunocytochemical analysis of NPC1 in HeLa cells.

By Natalia Gurule, PhD

 

Tags: 
Breast Cancer
Cancer
Cholesterol
EMT
Immunotherapy
Lysosome
Mitochondria
Triple-Negative Breast Cancer
TNBC
BRCA1
ErbB2/Her2
Niemann-Pick C1
PARP
Natalia Gurule

Hypoxia-Dependent CAR Stabilizing Construct in T cells Improves Solid Tumor Targeting and Efficacy

Banner image showing a chimeric antigen receptor (CAR) T cell.

By Victoria Osinski, PhD

Tags: 
Cancer
Chimeric Antigen Receptor
CAR-T
Hypoxia
immunology
Immunotherapy
Oxygen
T Cells
Tumor
Tumor Microenvironment
EGFR
ErbB2/Her2
ErbB3/Her3
ErbB4/Her4
HIF-1 alpha
Victoria Osinski

Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment

Banner image showing cancer cells in hypoxic conditions.

By Hunter Martinez

Tags: 
Adaptive Immunity
Hypoxia
immunology
metabolism
Mitochondria
Oxygen
ROS
T Cells
T cell exhaustion
T cell receptor
Tumor Microenvironment
BLIMP1/PRDM1
CD8
HIF-1 alpha
IFN-gamma
LAG-3
NFAT
NGFI-B alpha/Nur77/NR4A1
PD-1
PGC1 alpha
TIGIT
TNF-alpha
Hunter Martinez

Synthetic Biotic Medicine as Immunotherapy Against Cancer: Evidence From Arginine-Producing Engineered Bacteria

3D banner image showing example of pathogenic bacteria.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Bacteria
Cancer
Cancer Research
Checkpoint Blockade
Checkpoint Inhibitors
immunology
Immuno-oncology
Immunotherapy
Innate Immunity
L-arginine
T Cells
Tumor
ARG-2
CD4
CD8
PD-1
PD-L1
Jamshed Arslan

Harnessing Natural Killer Cell Activity for Anti-Tumor Immunotherapy

Banner image showing the workflow for Natural Killer (NK) cells.

By Victoria Osinski, PhD

Tags: 
Natural Killer Cell
NK Cell
Cancer
immunology
Immuno-oncology
Immunotherapy
CD8
MHC Class I
NKG2A/CD159a/KLRC1
NKG2C/CD159c/KLRC2
NKG2D/CD314
NKG2E/KLRC3
KLRC4
NKG2H
DAP12
Killer Cell Immunoglobulin-like Receptor
CD7
CD19
Siglec-3/CD33
MUC1
ErbB2/Her2
MICA
MICB
ULBP
HDAC
HLA G
KIR2DL4/CD158d
Victoria Osinski

Understanding ‘Y’ in Breast Cancer: Crucial Role of DNA/RNA-binding Protein YB-1 in the Development, Pre-Invasive, and Metastatic Phases

Akt expression in immersion fixed MDA-MB-231 breast cancer cell line using Mouse Anti-Akt Monoclonal Antibody and stained with NorthernLights 557-conjugated IgG Secondary Antibody.

Jamshed Arslan, Pharm D, PhD

Tags: 
Breast Cancer
Cancer
DNA Repair
YB1
HIF-1 alpha
NRF2
Kras
AKT1
G3BP1
Carbonic Anhydrase IX/CA9
VEGF
CD34
Jamshed Arslan

Taking Biomarker Discovery From 2D to 3D: Increased Biological Activity of EVs Isolated From 3D Prostate Cancer Cultures

3D rendering of extracellular vesicles released from cells as a banner image.

Jamshed Arslan, Pharm D, PhD

Tags: 
Cancer
cell culture
extracellular vesicles
Exosomes
Organoids
Prostate Cancer
Simple Western
PSMA/FOLH1/NAALADase I
CD44
Vimentin
Matrix Metalloproteinase
MMP
MUC1
EGR1
Flotillin-1
GDF-15
Jamshed Arslan

Using CometChip to Characterize Extracellular Regulators of DNA Repair: Does CD73 Levels in Cancer Cells Affect DNA Repair by Regulating Levels of Intracellular NAD+?

3D rendering of CometChip as a banner image.

By Natalia Gurule, PhD

 

Tags: 
Base Excision Repair
Cancer
CometAssay
CometChip
DNA Damage
DNA Repair
Metabolic Signaling
Tumor Microenvironment
TME
5’Nucleotidase/CD73
CD73
Nicotinamide Adenine Dinucleotide
NAD
PARP
Natalia Gurule

Autophagy and RAS signaling: Clinical implications

Immunocytochemical staining of fixed and permeabilized HeLa cells treated with chloroquine, incubated with LC3B (green) and tubulin (red) antibodies, and counterstained with DAPI to visualized DNA.

By Christina Towers, PhD

Tags: 
Autophagy
Cancer
Pancreatic Ductal Adenocarcinoma
Melanoma
Colorectal Cancer
Ras
LC3B
Beclin 1
mCherry
GFP
NRAS
B-Raf
CA19-9/Sialyl Lewis A
Christina Towers

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