OXPAT is the mammalian form of the PAT (perilipin, adipophilin, and TIP47) gene family that consists of proteins associated with lipid droplets (LDs) in fat-storing adipocyte cells.
The low density lipoprotein receptor coordinates the metabolism of cholesterol, an essential component of the mammalian cell plasma membranes. Study of this carefully balanced system has led to an enhanced understanding of cholesterol homeostasis at the cellular level. Receptor-mediated endocytosis (RME) is an important mechanism of metabolic regulation.
The low density lipoprotein receptor coordinates the metabolism of cholesterol, an essential component of the mammalian cell plasma membranes. Study of this carefully balanced system has led to an enhanced understanding of cholesterol homeostasis at the cellular level. Receptor-mediated endocytosis (RME) is an important mechanism of metabolic regulation.
Scavenger Receptor Class B Membrane 1, also known as SR-BI plays an important role in lipid metabolism. Its main function is to mediate transfer of cholesterol between the cell surface and high density lipoprotein (HDL). HDL acts as an extracellular donor and acceptor of free and esterified Cholesterol. SR-BI also acts as a receptor for other ligands including lipoproteins, apoptotic cells and phospholipids.
Obesity, diabetes and metabolic disorders are dramatically on the increase, linked to disorders such as heart disease, stroke and cancer. To combat this, research groups are studying metabolism at both a cellular and a systemic level.
