SUR1 Antibody (S289-16)

SUR1 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 4 of 4.

Publications using NBP2-59320	Applications	Species
Zhou J, Zhang Z, Yang Y et al. Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-beta oligomers Journal of neurochemistry 2022-07-15 [PMID: 35839294]
Yeh S, Hsu P, Yeh T et al. Capping Protein Regulator and Myosin 1 Linker 3 (CARMIL3) as a Molecular Signature of Ischemic Neurons in the DWI-T2 Mismatch Areas After Stroke Frontiers in Molecular Neuroscience 2021-12-16 [PMID: 34975397] (IF/IHC, Rat)	IF/IHC	Rat
Tsymbalyuk O, Gerzanich V, Mumtaz A et al. SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury Molecular pain 2021-03-31 [PMID: 33788643] (IF/IHC, Mouse)	IF/IHC	Mouse
Gerzanich V, Stokum J, Ivanova S et al. SUR1, TRPM4 and KIR6.2 - role in hemorrhagic progression of contusion. J. Neurotrauma 2018-08-30 [PMID: 30160201] (IF/IHC, Human)	IF/IHC	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Luiz Barella	WB	Mouse	02/25/2019	View Summary Application Western Blot Sample Tested Mouse pancreatic islets Species Mouse Lot 1205 Comments Comments Western Blot analysis of mouse pancreatic islets using Mouse Anti-SUR1 S289-16. Lane 1: Molecular Weight Ladder. Lanes 2-5: Samples from pooled pancreatic islets. Load: ~10 ug. Primary Antibody: Anti-SUR1 Monoclonal Antibody at 1:200 for ~16 hours at 4 degrees celsius. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT.
Enlarge	4 reviewed by: Verified Customer	IHC-P	Human	07/07/2017	View Summary Application Immunohistochemistry-Paraffin Sample Tested Human Tissue Sections - Pancreas Species Human Lot 1205 Comments Comments SUR1 was detected in immersion fixed paraffin-embedded sections of normal human pancreas using citrate pH6 pretreatment and incubating at 1:50 dilution for 30 minutes, with LabVision Quanto Detection.

Array NBP2-59320

• SUR1 Antibodies
• SUR1 ELISA Kits
• SUR1 Proteins