MED23 Antibody

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Chemotaxis.

Showing Publications 1 - 5 of 5.

Publications using NB200-337	Applications	Species
Telese F, Ma Q, Perez PM et al. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation Neuron 2015-04-16 [PMID: 25892301] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Grabrucker S, Proepper C, Mangu, et al. The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation. Exp. Neurol. 2014-03-01 [PMID: 24382453]
D'Alessio JA, Ng R, Willenbring H, Tjian R. Core promoter recognition complex changes accompany liver development. Proc Natl Acad Sci U S A. 2011-02-22 [PMID: 21368148]
Yang M, Hay J, Ruyechan WT et al. Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activation. J Virol 2008-12-01 [PMID: 18842726]
Meyer KD, Donner AJ, Knuesel MT et al. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J 2008-05-01 [PMID: 18418385]

Array NB200-337

• MED23 Antibodies
• MED23 Protein