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SUR1 Antibody (S289-16) [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, Rt, HaSpecies Glossary
Applications ICC/IF, IHC
Clone
S289-16
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

SUR1 Antibody (S289-16) [Biotin] Summary

Immunogen
Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
Localization
Membrane
Specificity
Detects 160kDa. Does not cross-react with SUR2B.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ABCC8
Purity
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for SUR1 Antibody (S289-16) [Biotin]

  • ABC36
  • ABCC8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • HHF1Sulfonylurea receptor 1
  • HI
  • HRINS
  • PHHIHRINS
  • sulfonylurea receptor (hyperinsulinemia)
  • SUR
  • SUR1
  • SUR1MRP8
  • SURATP-binding cassette transporter sub-family C member 8
  • TNDM2ATP-binding cassette sub-family C member 8

Background

SUR1 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ABCC8