SUR1 Products

Description

SUR1 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

Bioinformatics

Entrez	20927 Mouse 25559 Rat 6833 Human
Uniprot	NM_000352 Human NP_000343 Human NP_000343.2 Human Q09428 Human
Product By Gene ID	6833
Alternate Names	ABC36 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 HHF1Sulfonylurea receptor 1 HI PHHIHRINS sulfonylurea receptor (hyperinsulinemia) SUR1MRP8 SURATP-binding cassette transporter sub-family C member 8 TNDM2ATP-binding cassette sub-family C member 8

Research Areas for SUR1

Find related products by research area and learn more about each of the different research areas below.

ABC Transporters
Lipid and Metabolism
Nutrient Sensing in the Brain