XBP1 Antibody - BSA Free

X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-77252	Applications	Species
Hao L, Sun Q, Zhong W et al. Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease Redox Biol. [PMID: 29156373] (WB)	WB
Park Sh, Shin D, Lim Ss et al. Purple Perilla Extracts Allay ER Stress in Lipid-Laden Macrophages. PLoS OnE. 2014-10-22 [PMID: 25333946] (WB)	WB

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Wenliang Zhang	WB	Mouse	02/09/2018	View Summary Application Western Blot Sample Tested mouse liver Species Mouse Lot 3685-0504

Array NBP1-77252

• XBP1 Antibodies
• XBP1 Lysates
• XBP1 Proteins