WIF-1 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

WIF (Wnt Inhibitory Factor) is a secreted protein that binds to Wnt proteins and inhibits their activity. The protein is synthesized as a 379 amino acid (aa) molecule that contains an N-terminal signal sequence, 150 aa WIF domain, 5 EGF-like repeats, and a hydrophilic domain at the carboxy terminus (1). In situ hybridization analysis from the frog, Xenopus laevis, and zebrafish indicate that the message is highly expressed in presomitic mesoderm, the notochord, anterior regions of the brain, branchial arches, nasal placodes, and otic vescicles (1). WIF inhibits secondary axis induction by Wnts and promotes secondary axis induction by Chordin in Xenopus embryos (1). In vitro, WIF binds to Drosophila Wingless and Xenopus Wnt‑8 proteins (1). WIF-1 is implicated as an early event tumor suppressor in cancers of the prostate, breast, lung and bladder (2). However, WIF-1’s role in carcinogenesis may not be that simple since in other cancer types, such as colon adenocarcinoma, WIF facilitates tumorigenesis (3). Human WIF-1 shares 94% and 82% amino acid identity with mouse and frog, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 3 of 3.

Publications using AF134	Applications	Species
K Kerekes, M Trexler, L Bányai, L Patthy Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog Cells, 2021-12-10;10(12):. 2021-12-10 [PMID: 34944004] (Western Blot, Human)	Western Blot	Human
Hu J, Dong A, Fernandez-Ruiz V, Shan J, Kawa M, Martinez-Anso E, Prieto J, Qian C Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res., 2009-08-18;69(17):6951-9. 2009-08-18 [PMID: 19690140] (Western Blot, Human)	Western Blot	Human
Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL Gene induction during differentiation of human pulmonary type II cells in vitro. Am. J. Respir. Cell Mol. Biol., 2006-02-10;34(6):727-37. 2006-02-10 [PMID: 16474099] (Western Blot, Human)	Western Blot	Human

Array AF134

• WIF-1 Antibodies
• WIF-1 Lysate
• WIF-1 Proteins and Enzymes
• WIF-1 ELISA