Recombinant Mouse sFRP-2 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Secreted Frizzled Related Protein-2 (sFRP-2) belongs to a family of Wnt-binding proteins with homology to the ligand-binding domain of the Frizzled transmembrane Wnt receptors. The sFRP proteins are approximately 30 - 35 kDa in size and contain an N-terminal Frizzled-like domain with 10 conserved cysteines and a Netrin-like C-terminal domain (1, 2). Mature mouse sFRP-2, also known as SARP-1, SDF-5, and FRP-2, shares 99% aa sequence identity with human and rat sFRP-2 (3, 4). sFRP-2 is widely expressed during embryogenesis and in the adult in tissues including the eye, heart, lung, colon, intestine, smooth muscle, pancreas, prostate, testis, kidney, brain, teeth and joints, craniofacial mesenchyme, and preadipocytes (3 - 6). Depending on the context, sFRP-2 can exert either positive or negative effects on Wnt signaling (7 - 9). It also inhibits BMP-induced effects [Alfaro 35646, Oshima 3160]. sFRP-2 can be incorporated into the extracellular matrix through interactions with Fibronectin and Integrin alpha 5 beta 1 (11). sFRP-2 plays a variety of roles during tissue morphogenesis including inhibition of the planar cell polarity pathway and myoblast and osteoblast differentiation (8, 10, 12, 13). sFRP-2 is also expressed in multiple myeloma and glioma in which it promotes tumorigenicity (10, 14). At physiological concentrations sFRP-2 enhances BMP-1 mediated proteolysis of Pro-Collagen I, whereas at higher concentrations it inhibits BMP-1 activity (15, 16). This difference is significant considering that sFRP‑2 is up‑regulated in fibrotic areas of the heart following myocardial infarction (15, 16). Elevated levels of sFRP-2 then promote the recovery of cardiac function by reducing collagen deposition, remodeling, and calcification and by promoting the engraftment of mesenchymal stem cells into the heart (8, 15).

We have publications tested in 3 confirmed species: Mouse, Rat, Chicken.

We have publications tested in 5 applications: Bioassay, Cell Culture, In Vivo, Surface Plasmon Resonance, Western Blot Control.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using 1169-FR	Applications	Species
Shimizu, K;Kikuta, J;Ohta, Y;Uchida, Y;Miyamoto, Y;Morimoto, A;Yari, S;Sato, T;Kamakura, T;Oshima, K;Imai, R;Liu, YC;Okuzaki, D;Hara, T;Motooka, D;Emoto, N;Inohara, H;Ishii, M; Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction Nature communications 2023-08-03 [PMID: 37537159] (Cell Culture, Mouse)	Cell Culture	Mouse
E Ramos-Fern, MS Arrázola, CA Oliva, SB Arredondo, L Varela-Nal, NC Inestrosa Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2&alpha HRI kinase Scientific Reports, 2021-04-01;11(1):7395. 2021-04-01 [PMID: 33795747] (Bioassay, Mouse)	Bioassay	Mouse
M Montagner, R Bhome, S Hooper, P Chakravart, X Qin, J Sufi, A Bhargava, CDH Ratcliffe, Y Naito, A Pocaterra, CJ Tape, E Sahai Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination Nat. Cell Biol., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094692] (Western Blot Control)	Western Blot Control
C Chen, Y Yang, Y Yao HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/beta-Catenin and BMP2 Signaling Pathways Cell Transplant, 2019-11-06;0(0):9636897198835. 2019-11-06 [PMID: 31694396] (Rat)		Rat
P Periasamy, V Tran, HC O'Neill Identification of genes which regulate stroma-dependent in vitro hematopoiesis PLoS ONE, 2018-10-11;13(10):e0205583. 2018-10-11 [PMID: 30308055] (Bioassay, Mouse)	Bioassay	Mouse
Godoy J, Arrazola M, Ordenes D, Silva-Alvarez C, Braidy N, Inestrosa N Wnt-5a ligand modulates mitochondrial fission-fusion in rat hippocampal neurons. J Biol Chem, 2014-10-21;289(52):36179-93. 2014-10-21 [PMID: 25336659] (Bioassay, Rat)	Bioassay	Rat
Yamamoto-Shiraishi Y, Kuroiwa A Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. 2013-03-13;0(0):. 2013-03-13 [PMID: 23499659] (In Vivo, Mouse)	In Vivo	Mouse
Tran , Thanh H, Shi , Xiaofeng, Zaia , Joseph, Ai , Xingbin Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem, 2012-08-03;287(39):32651-64. 2012-08-03 [PMID: 22865881] (Bioassay, Mouse)	Bioassay	Mouse
Wawrzak D, Metioui M, Willems E, Hendrickx M, de Genst E, Leyns L Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun., 2007-04-19;357(4):1119-23. 2007-04-19 [PMID: 17462603] (Bioassay, Surface Plasmon Resonance, Mouse)	Bioassay, Surface Plasmon Resonance	Mouse
Canning CA, Lee L, Irving C, Mason I, Jones CM Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity. Dev. Biol., 2007-02-16;305(1):276-86. 2007-02-16 [PMID: 17383629] (Bioassay, Chicken)	Bioassay	Chicken
Schmidt C, Stoeckelhuber M, McKinnell I, Putz R, Christ B, Patel K Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation. Dev. Biol., 2004-07-01;271(1):198-209. 2004-07-01 [PMID: 15196961] (In Vivo, Chicken)	In Vivo	Chicken
Polesskaya A, Seale P, Rudnicki MA Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell, 2003-06-27;113(7):841-52. 2003-06-27 [PMID: 12837243] (In Vivo, Mouse)	In Vivo	Mouse
Show All 12 Publications. Collapse Publications.

Array 1169-FR

• sFRP-2 Antibodies
• sFRP-2 Lysate
• sFRP-2 Proteins and Enzymes