Name: VEGFR3/Flt-4 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF349
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, IHC
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF349

Immunogen	Mouse myeloma cell line NS0-derived recombinant human VEGFR3/Flt-4 Tyr25-Ile776 Accession # P35916
Specificity	Detects human VEGFR3/Flt-4 in direct ELISAs and Western blots. In Western blots, approximately 15% cross-reactivity with recombinant mouse VEGFR3 is observed and less than 2% cross-reactivity with recombinant human VEGFR1 is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	FLT4
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

VEGFR3/Flt-4 Antibody [Unconjugated]

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VEGFR3/Flt-4 Antibody [Unconjugated] Summary

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Publications for VEGFR3/Flt-4 Antibody (AF349)(27)

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Bioinformatics

Publications using AF349	Applications	Species
Creff, J;Lamaa, A;Benuzzi, E;Balzan, E;Pujol, F;Draia-Nicolau, T;Nougué, M;Verdu, L;Morfoisse, F;Lacazette, E;Valet, P;Chaput, B;Gross, F;Gayon, R;Bouillé, P;Malloizel-Delaunay, J;Bura-Rivière, A;Prats, AC;Garmy-Susini, B; Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema EMBO molecular medicine 2024-01-02 [PMID: 38177539] (Western Blot, Human)	Western Blot	Human
Jannaway, M;Iyer, D;Mastrogiacomo, DM;Li, K;Sung, DC;Yang, Y;Kahn, ML;Scallan, JP; VEGFR3 is required for button junction formation in lymphatic vessels Cell reports 2023-07-15 [PMID: 37454290] (IHC, Mouse)	IHC	Mouse
A Das, D Ash, AY Fouda, V Sudhahar, YM Kim, Y Hou, FZ Hudson, BK Stansfield, RB Caldwell, M McMenamin, R Littlejohn, H Su, MR Regan, BJ Merrill, LB Poole, JH Kaplan, T Fukai, M Ushio-Fuka Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis Nature Cell Biology, 2022-01-13;24(1):35-50. 2022-01-13 [PMID: 35027734] (Immunoprecipitation, Human)	Immunoprecipitation	Human
M Park, J Kim, T Kim, S Kim, W Park, KS Ha, SH Cho, MH Won, JH Lee, YG Kwon, YM Kim REDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression Experimental & Molecular Medicine, 2021-10-25;0(0):. 2021-10-25 [PMID: 34697389] (Western Blot, Human)	Western Blot	Human
BR Thomson, P Liu, T Onay, J Du, SW Tompson, S Misener, RR Purohit, TL Young, J Jin, SE Quaggin Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies Nature Communications, 2021-10-18;12(1):6072. 2021-10-18 [PMID: 34663817] (IHC, Mouse)	IHC	Mouse
Simon Bernatz, Daniel Monden, Florian Gessler, Tijana Radic, Elke Hattingen, Christian Senft et al. Influence of VEGF-A, VEGFR-1-3, and neuropilin 1-2 on progression-free: and overall survival in WHO grade II and III meningioma patients Journal of Molecular Histology 4/1/2021 [PMID: 33528717]
P Ella-Tongw, RM Lamb, A Makanga, I Shergill, SF Hughes The role of antibody expression and their association with bladder cancer recurrence: a single-centre prospective clinical-pilot study in 35 patients BMC Urol, 2020-11-25;20(1):187. 2020-11-25 [PMID: 33238953] (IHC-P, Human)	IHC-P	Human
ST Wei, YC Huang, ML Hsieh, YJ Lin, WC Shyu, HC Chen, CH Hsieh Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling Cell Death Dis, 2020-05-04;11(5):307. 5/4/2020 [PMID: 32366833]
Sofia Urner, Lara Planas‐Paz, Laura Sophie Hilger, Carina Henning, Anna Branopolski, Molly Kelly‐Goss et al. Identification of ILK as a critical regulator of VEGFR 3 signalling and lymphatic vascular growth The EMBO Journal 1/15/2019 [PMID: 30518533]
LD Volk-Drape, KL Hall, AC Wilber, S Ran Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4 PLoS ONE, 2017-06-09;12(6):e0179257. 2017-06-09 [PMID: 28598999] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
K Heinolaine, S Karaman, G D'Amico, T Tammela, R Sormunen, L Eklund, K Alitalo, G Zarkada VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling Circ. Res, 2017-03-15;0(0):. 2017-03-15 [PMID: 28298294] (Western Blot, Human)	Western Blot	Human
Tom J Parry Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction Eur. J. Pharmacol, 2016-12-16;796(0):76-89. 2016-12-16 [PMID: 27993643] (Western Blot, Human)	Western Blot	Human
Masaaki Miyazawa Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance J. Exp. Med., 2016-11-04;0(0):. 2016-11-04 [PMID: 27815325] (IHC-Fr, Mouse)	IHC-Fr	Mouse
TGF-?1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT) PLoS ONE, 2016-09-02;11(9):e0162221. 2016-09-02 [PMID: 27589056] (Western Blot, Human)	Western Blot	Human
Wakisaka N, Hasegawa Y, Yoshimoto S, Miura K, Shiotani A, Yokoyama J, Sugasawa M, Moriyama-Kita M, Endo K, Yoshizaki T Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma. PLoS ONE, 2015-12-02;10(12):e0144056. 2015-12-02 [PMID: 26630663] (IHC-P, Human)	IHC-P	Human
Brian G. Coon, Nicolas Baeyens, Jinah Han, Madhusudhan Budatha, Tyler D. Ross, Jennifer S. Fang et al. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex Journal of Cell Biology 3/30/2015 [PMID: 25800053]
Lee , Esak, Pandey , Niranjan, Popel , Aleksand Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep, 2014-07-28;4(0):5853. 2014-07-28 [PMID: 25068296] (IHC, Human)	IHC	Human
Omoto , Itaru, Matsumoto , Masataka, Okumura , Hiroshi, Uchikado , Yasuto, Setoyama , Tetsuro, Kita , Yoshiaki, Owaki , Tetsuhir, Kijima , Yuko, Shinchi , Hiroyuki, Ishigami , Sumiya, Ueno , Shinichi, Natsugoe , Shoji Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma. Oncol Lett, 2014-01-24;7(4):1027-1032. 2014-01-24 [PMID: 24944663] (IHC, Human)	IHC	Human
Jennifer M. Davis, Elizabeth Hyjek, Aliya N. Husain, Le Shen, Jennifer Jones, Lucia A. Schuger Lymphatic Endothelial Differentiation in Pulmonary Lymphangioleiomyomatosis Cells Journal of Histochemistry & Cytochemistry 8/1/2013 [PMID: 23609227]
Junichi Fukuhara, Satoru Kase, Tsutomu Ohashi, Ryo Ando, Zhenyu Dong, Kousuke Noda et al. Expression of vascular endothelial growth factor C in human pterygium Histochemistry and Cell Biology 2/1/2013 [PMID: 22910845]
Sanja Coso, Yiping Zeng, Kenneth Opeskin, Elizabeth D. Williams Vascular Endothelial Growth Factor Receptor-3 Directly Interacts with Phosphatidylinositol 3-Kinase to Regulate Lymphangiogenesis PLoS ONE 6/22/2012 [PMID: 22745786]
Lara Planas-Paz, Boris Strilić, Axel Goedecke, Georg Breier, Reinhard Fässler, Eckhard Lammert Mechanoinduction of lymph vessel expansion The EMBO Journal 2/15/2012 [PMID: 22157817]
Thelen A, Scholz A, Benckert C, Von Marschall Z, Schroder M, Wiedenmann B, Neuhaus P, Rosewicz S, Jonas S VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma. Int. J. Cancer, 2008-06-01;122(11):2471-81. 2008-06-01 [PMID: 18338756] (IHC, Human)	IHC	Human
Su JL, Shih JY, Yen ML, Jeng YM, Chang CC, Hsieh CY, Wei LH, Yang PC, Kuo ML Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res., 2004-01-15;64(2):554-64. 2004-01-15 [PMID: 14744769] (IHC-P, Western Blot, Human)	IHC-P, Western Blot	Human
Bairey O, Boycov O, Kaganovsky E, Zimra Y, Shaklai M, Rabizadeh E All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells. Leuk. Res., 2004-03-01;28(3):243-8. 2004-03-01 [PMID: 14687619] (ICC, Human)	ICC	Human
Yokoyama Y, Charnock-Jones DS, Licence D, Yanaihara A, Hastings JM, Holland CM, Emoto M, Sakamoto A, Sakamoto T, Maruyama H, Sato S, Mizunuma H, Smith SK Expression of vascular endothelial growth factor (VEGF)-D and its receptor, VEGF receptor 3, as a prognostic factor in endometrial carcinoma. Clin. Cancer Res., 2003-04-01;9(4):1361-9. 2003-04-01 [PMID: 12684405] (IHC-P, Human)	IHC-P	Human
Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops. Int. J. Cancer, 2003-05-01;104(5):603-10. 2003-05-01 [PMID: 12594815] (ICC, Immunoprecipitation, Western Blot, Human)	ICC, Immunoprecipitation, Western Blot	Human
Show All 27 Publications. Collapse Publications.

Catalog# & Formulation	Size	Price
Carrier Free AF349-SP

Gene Symbol	FLT4
Uniprot	P35916()