UPF2 Antibody

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-20813	Applications	Species
Cheruiyot A, Li S, Nickless A et al. Compound C inhibits nonsense-mediated RNA decay independently of AMPk. PLoS ONE. 2018-10-05 [PMID: 30289931] (WB, Human)	WB	Human
Nickless A, Jackson E, Marasa J et al. Intracellular calcium regulates nonsense-mediated mRNA decay. Nat. Med. 2014-07-27 [PMID: 25064126] (WB, Human) Details: UPF2 antibody used for WB in shRNA-mediated UPF2 knockdown U2OS -nonsense-mediated mRNA decay/NMD reporter (multicolored bioluminescence-based reporter system) cells. WB image - Figure 1e.	WB	Human

Array NBP2-20813

• UPF2 Antibodies
• UPF2 Protein