Tyk2 Antibody Summary
| Immunogen |
Recombinant protein within human Tyk2 aa 390-620. (SwissProt: P29597 Human; SwissProt: Q9R117 Mouse) |
| Localization |
Cytoskeleton. Nucleus. Cytosol. Plasma membrane. |
| Isotype |
IgG |
| Clonality |
Polyclonal |
| Host |
Rabbit |
| Gene |
TYK2 |
| Purity |
Immunogen affinity purified |
| Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
| Dilutions |
- Flow Cytometry 1:50-1:100
- Immunocytochemistry/ Immunofluorescence 1:50-1:200
- Immunohistochemistry
- Immunohistochemistry-Paraffin 1:50-1:200
- Western Blot 1:500
|
| Theoretical MW |
134 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Buffer |
PBS (pH7.4), 0.2% BSA, 50% Glycerol |
| Preservative |
0.05% Sodium Azide |
| Concentration |
1 mg/ml |
| Purity |
Immunogen affinity purified |
Alternate Names for Tyk2 Antibody
Background
Novel non-receptor tyrosine-protein kinase, Tyk2, belongs to the tyrosine protein kinase family and plays a role in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Tyk2 is believed to phosphorylate the interferon-alpha/beta receptor alpha chain (1). It has been shown that Tyk2 links the interferon alpha/beta receptor to the cytoplasmic transcription factor that mediates activation of interferon-responsive genes (2).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
Video Protocols
FAQs for Tyk2 Antibody (NBP2-76968) (0)
![Western Blot: Tyk2 Antibody [NBP2-76968] - Western blot analysis of TYK2 on MCF-7 cell lysate using anti-TYK2 antibody at 1/500 dilution.](http://images.novusbio.com/fullsize/Tyk2-Antibody-Western-Blot-NBP2-76968-img0001.jpg "Western Blot: Tyk2 Antibody [NBP2-76968] - Western blot analysis of TYK2 on MCF-7 cell lysate using anti-TYK2 antibody at 1/500 dilution.")
![Western Blot Jak1 Antibody (413104) [Unconjugated]](https://images.novusbio.com/images2/Jak1_MAB4260_Western_Blot_6164.jpg)
![Immunocytochemistry/Immunofluorescence: Tyk2 Antibody [NBP2-76968] - ICC staining TYK2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.](http://images.novusbio.com/fullsize/Tyk2-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-76968-img0002.jpg "Immunocytochemistry/Immunofluorescence: Tyk2 Antibody [NBP2-76968] - ICC staining TYK2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.")
![Immunohistochemistry: Tyk2 Antibody [NBP2-76968] - Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti- TYK2 antibody. Counter stained with hematoxylin.](http://images.novusbio.com/fullsize/Tyk2-Antibody-Immunohistochemistry-NBP2-76968-img0005.jpg "Immunohistochemistry: Tyk2 Antibody [NBP2-76968] - Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti- TYK2 antibody. Counter stained with hematoxylin.")
![Flow Cytometry: Tyk2 Antibody [NBP2-76968] - Flow cytometric analysis of MCF-7 cells with TYK2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; green). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.](http://images.novusbio.com/fullsize/Tyk2-Antibody-Flow-Cytometry-NBP2-76968-img0006.jpg "Flow Cytometry: Tyk2 Antibody [NBP2-76968] - Flow cytometric analysis of MCF-7 cells with TYK2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; green). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.")
![Immunohistochemistry: Tyk2 Antibody [NBP2-76968] - Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-TYK2 antibody. Counter stained with hematoxylin.](http://images.novusbio.com/fullsize/Tyk2-Antibody-Immunohistochemistry-NBP2-76968-img0003.jpg "Immunohistochemistry: Tyk2 Antibody [NBP2-76968] - Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-TYK2 antibody. Counter stained with hematoxylin.")
![Immunohistochemistry: Tyk2 Antibody [NBP2-76968] - Immunohistochemical analysis of paraffin-embedded human colon tissue using anti- TYK2 antibody. Counter stained with hematoxylin.](http://images.novusbio.com/fullsize/Tyk2-Antibody-Immunohistochemistry-NBP2-76968-img0004.jpg "Immunohistochemistry: Tyk2 Antibody [NBP2-76968] - Immunohistochemical analysis of paraffin-embedded human colon tissue using anti- TYK2 antibody. Counter stained with hematoxylin.")
![Immunohistochemistry Jak1 Antibody (413104) [Unconjugated]](https://images.novusbio.com/images2/Jak1_MAB4260_Immunohistochemistry_7021.jpg)
![Intracellular Staining by Flow Cytometry Jak1 Antibody (413104) [Unconjugated]](https://images.novusbio.com/images2/Jak1_MAB4260_Flow_Cytometry_8448.jpg)
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![Knockout Validated STAT3 Antibody (232209) [Unconjugated]](https://images.novusbio.com/images2/STAT3_MAB1799_Knockout_Validated_21531.jpg)
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![Simple Western STAT2 [p Tyr690] Antibody (1021D) [Unconjugated]](https://images.novusbio.com/images2/16353.jpg)
![Western Blot STAT2 [p Tyr690] Antibody (1021D) [Unconjugated]](https://images.novusbio.com/images2/STAT2_MAB2890_Western_Blot_14700.jpg)
![Western Blot STAT2 [p Tyr690] Antibody (1021D) [Unconjugated]](https://images.novusbio.com/images/mab2890_human-phospho-stat2-y690-mab-clone-1021d-4120241339246.jpg)
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![N/A IL-6 [HRP]](https://images.novusbio.com/images/m6000b_mouse-il-6-quantikine-elisa-kit-44202415433118.jpg)
![Simple Western STAT5b Antibody [Unconjugated]](https://images.novusbio.com/images2/16321.jpg)
![Knockout Validated STAT5b Antibody [Unconjugated]](https://images.novusbio.com/images2/STAT5b_AF1584_Knockout_Validated_21968.jpg)
![Immunocytochemistry STAT5b Antibody [Unconjugated]](https://images.novusbio.com/images2/STAT5b_AF1584_Immunocytochemistry__Immunofluorescence_17603.jpg)
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![Chromatin Immunoprecipitation (ChIP) STAT5a/b Antibody [Unconjugated] - Pan Specific](https://images.novusbio.com/images2/STAT5b_AF2168_Chromatin_Immunoprecipitation_11246.jpg)
![Bioactivity IL-4 [Unconjugated]](https://images.novusbio.com/images/protein/6507-ilcf_recombinant-human-il-4-cho-expressed-protein-cf-bioactivity-272020133214.jpg)
![Bioactivity IFN-gamma [Unconjugated]](https://images.novusbio.com/images2/IFNgamma_285IF_2848.jpg)
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![Western Blot: Goat anti-Rabbit IgG (H+L) Secondary Antibody [HRP] [NB7160] - Western blot showing vemurafenib treatment in BRAFV600E CRC cells inhibits fission mediator DRP1 with no significant effect on fusion proteins (Mfn1 & 2) using MFN-1 antibody (NBP1-51841) and corresponding secondary antibody, goat anti-rabbit IgG-HRP (NB7160). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33738242).](https://images.novusbio.com/images/Goat-anti-Rabbit-IgG-H+L-Secondary-Antibody-HRP-Western-Blot-NB7160-img0001.jpg "Western Blot: Goat anti-Rabbit IgG (H+L) Secondary Antibody [HRP] [NB7160] - Western blot showing vemurafenib treatment in BRAFV600E CRC cells inhibits fission mediator DRP1 with no significant effect on fusion proteins (Mfn1 & 2) using MFN-1 antibody (NBP1-51841) and corresponding secondary antibody, goat anti-rabbit IgG-HRP (NB7160). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33738242).")
![Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary.](https://images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0001.jpg "Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary.")