TTF-1 / NKX2-1 Antibody (SPM150)

The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype (1). Thyroid dysgenesis (TD) is responsible for most cases of congenital hypothyroidism, a condition that affects about one in 4000 newborns. Mutations in PAX8, TTF1, or FOXE1 may account for congenital hypothyroidism in patients with either isolated TD or TD with associated malformations involving kidney, lung, forebrain, and palate (2). In addition to its presence in thyroid gland epithelium, the human TTF-1 protein was detected by immunohistochemistry in human fetal lung as early as 11 weeks of gestation, being localized in the nuclei of epithelial cells of the developing airways. After birth, TTF-1 was selectively expressed in Type II epithelial cells in the alveoli and in subsets of bronchiolar epithelial cells in the conducting regions of the lung (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP2-32999	Applications	Species
Scortegagna M, Du Y, Bradley LM et al. Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma Cancer research 2023-04-19 [PMID: 37078793]

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	IHC-P	Human	03/04/2022	View Summary Application Immunohistochemistry-Paraffin Sample Tested Lung carcinoma Species Human Lot SPM150 Comments Comments Incubated O/N in 4 C with the 1ry antibody, 1.0ug/ml

Array NBP2-32999

• TTF-1 / NKX2-1 Antibodies
• TTF-1 / NKX2-1 ELISA Kits
• TTF-1 / NKX2-1 Lysates
• TTF-1 / NKX2-1 Protein