TTF-1 / NKX2-1 Products

Description

The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype (1). Thyroid dysgenesis (TD) is responsible for most cases of congenital hypothyroidism, a condition that affects about one in 4000 newborns. Mutations in PAX8, TTF1, or FOXE1 may account for congenital hypothyroidism in patients with either isolated TD or TD with associated malformations involving kidney, lung, forebrain, and palate (2). In addition to its presence in thyroid gland epithelium, the human TTF-1 protein was detected by immunohistochemistry in human fetal lung as early as 11 weeks of gestation, being localized in the nuclei of epithelial cells of the developing airways. After birth, TTF-1 was selectively expressed in Type II epithelial cells in the alveoli and in subsets of bronchiolar epithelial cells in the conducting regions of the lung (3).

Bioinformatics

Entrez	21869 Mouse 22130 Mouse 25628 Rat 362809 Rat 499766 Rat 56351 Mouse 7080 Human
Uniprot	AAH06221 Human NM_003317 Human NP_001073136 Human NP_003308 Human NP_003308.1 Human P23441 Rat P43699 Human P43699 Human
Product By Gene ID	7080
Alternate Names	benign chorea Homeobox protein NK-2 homolog A homeobox protein Nkx-2.1 NK2 homeobox 1 NK-2 homolog A NKX2ANKX2.1 Thyroid nuclear factor 1 Thyroid transcription factor 1BHC TITF1TEBP TTF1 TTF1BCH TTF-1NK-2

Research Areas for TTF-1 / NKX2-1

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones