UVRAG Antibody

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ICC/IF, IP, KO, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-18885	Applications	Species
Li X, Yang KB, Chen W et al. CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression Autophagy 2021-05-12 [PMID: 33977871]
Aikawa C, Nakajima S, Karimine M et al. NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex Front Cell Dev Biol. 2018-11-13 [PMID: 30488027] (KO, ICC/IF, IP, Human)	KO, ICC/IF, IP	Human
Sun T, Li X, Zhang P et al. Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Nat Commun. 2015-05-26 [PMID: 26008601] (WB, Human)	WB	Human

Array NBP1-18885

• UVRAG Antibodies
• UVRAG Lysate
• UVRAG Proteins