TSLP Antibody Blocking Peptide

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. Despite its predicted molecular weight, TSLP often migrates at a higher molecular weight in SDS-PAGE. At least two differentially spliced isoforms of TSLP are known to exist.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Publication using NB110-55234PEP	Applications	Species
Buchheit KM, Cahill KN, Katz HR et al. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol. 2015-12-12 [PMID: 26691435] Details: TSLP antibody was used for WB analysis of lysates from nasal polyp samples of patients with aspirin-exacerbated respiratory disease/AERD (Fig 4; Fig E3). The antibody was tested for specificity using its corresponding blocking peptide NB110-55234PEP and was also compared with anti-TSLP antibody (ABT330 from Millipore; Fig E2).

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Ming Hua	Binding assay/Protein-protein interaction		07/01/2017	View Summary Application Binding assay/Protein-protein interaction Comments The neutralizing/blocking peptideNB110-55234PEP (Novus Biologicals) work well in Western blot analysis. Comments Comments The blot was stripped of bound antibody and incubated for 1 hour with 1 mL/mL of the neutralizing/blocking peptide NB110-55234PEP (Novus Biologicals), which was used as an immunogen for NB110-55234

Array NB110-55234PEP

• TSLP Antibodies
• TSLP Kit
• TSLP Lysate
• TSLP Proteins
• TSLP Proteins and Enzymes
• TSLP ELISAs