Genetic Strategies: Western Blot: Trim22 Antibody [NBP1-81795] - Analysis in U-87MG ATCC cells transfected with control siRNA, target specific siRNA probe #1 and #2, using anti-TRIM22 antibody. Remaining relative ...read more
Immunocytochemistry/ Immunofluorescence: Trim22 Antibody [NBP1-81795] - Staining of human cell line ASC TERT1 shows localization to nucleoplasm, nuclear bodies & the Golgi apparatus. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Trim22 Antibody [NBP1-81795] - Staining of human placenta shows moderate cytoplasmic positivity in trophoblastic cells.
Immunohistochemistry-Paraffin: Trim22 Antibody [NBP1-81795] - Staining of human spleen shows strong nuclear and cytoplasmic positivity in cells in white and red pulp.
Immunohistochemistry-Paraffin: Trim22 Antibody [NBP1-81795] - Staining of human ovary shows strong nuclear positivity in ovarian stromal cells.
Immunohistochemistry-Paraffin: Trim22 Antibody [NBP1-81795] - Staining of human lymph node shows strong nuclear and cytoplasmic positivity in germinal center and non-germinal center cells.
Immunohistochemistry-Paraffin: Trim22 Antibody [NBP1-81795] - Staining of human small intestine shows strong nuclear and cytoplasmic positivity in glandular cells.
This antibody was developed against Recombinant Protein corresponding to amino acids: NEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRV
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TRIM22
Purity
Immunogen affinity purified
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Reactivity reported in scientific literature (PMID: 23448979)
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Trim22 Antibody
50 kDa-stimulated trans-acting factor
E3 ubiquitin-protein ligase TRIM22
EC 6.3.2
EC 6.3.2.-
GPSTAF50
RING finger protein 94
RNF94stimulated trans-acting factor (50 kDa)
Staf-50
STAF50staf-50
tripartite binding motif 22
tripartite motif containing 22
tripartite motif protein TRIM22
tripartite motif-containing 22
Tripartite motif-containing protein 22
Background
Trim22 is encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. [provided by RefSeq]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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