Immunocytochemistry/ Immunofluorescence: Treacher Collins syndrome protein Antibody [NBP1-86909] - Staining of human cell line A-431 shows localization to nucleoli fibrillar center. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Treacher Collins syndrome protein Antibody [NBP1-86909] - Staining of human colon shows weak to moderate nuclear and nucleolar positivity in glandular cells.
Immunohistochemistry-Paraffin: Treacher Collins syndrome protein Antibody [NBP1-86909] - Staining of human Fallopian tube shows strong nuclear positivity in glandular cells.
Immunohistochemistry-Paraffin: Treacher Collins syndrome protein Antibody [NBP1-86909] - Staining of human testis shows moderate to strong nuclear and nucleolar positivity in cells in seminiferous ducts.
Treacher Collins syndrome protein Antibody Summary
Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: ESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPK
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TCOF1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Use in Zebrafish reported in scientific literature (PMID:32231306).
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Treacher Collins syndrome protein Antibody
MFD1
nucleolar trafficking phosphoprotein
TCS1
Treacher Collins syndrome protein
Treacher Collins-Franceschetti syndrome 1
treacle protein
treacle
Background
This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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