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Treacher Collins syndrome protein Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: Treacher Collins syndrome protein Antibody [NBP1-86909] - Staining of human cell line A-431 shows localization to nucleoli fibrillar center. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Treacher Collins syndrome protein Antibody [NBP1-86909] - Staining of human colon shows weak to moderate nuclear and nucleolar positivity in glandular cells.
Immunohistochemistry-Paraffin: Treacher Collins syndrome protein Antibody [NBP1-86909] - Staining of human Fallopian tube shows strong nuclear positivity in glandular cells.
Immunohistochemistry-Paraffin: Treacher Collins syndrome protein Antibody [NBP1-86909] - Staining of human testis shows moderate to strong nuclear and nucleolar positivity in cells in seminiferous ducts.

Product Details

Summary
Reactivity Hu, ZeSpecies Glossary
Applications ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Treacher Collins syndrome protein Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: ESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPK
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TCOF1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Control Peptide
Treacher Collins syndrome protein Protein (NBP1-86909PEP)
Publications
Read Publications using
NBP1-86909 in the following applications:

Reactivity Notes

Use in Zebrafish reported in scientific literature (PMID:32231306).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Treacher Collins syndrome protein Antibody

  • MFD1
  • nucleolar trafficking phosphoprotein
  • TCS1
  • Treacher Collins syndrome protein
  • Treacher Collins-Franceschetti syndrome 1
  • treacle protein
  • treacle

Background

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Treacher Collins syndrome protein Antibody (NBP1-86909)(3)

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TCOF1