Transglutaminase 2/TGM2 Antibody Summary
Immunogen |
A portion of amino acids 600-650 of human Transglutaminase 2 was used as the immunogen. |
Predicted Species |
Chimpanzee (93%), Monkey (93%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
TGM2 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry
- Immunohistochemistry-Paraffin 1-2 ug/ml
- Simple Western 1:50
- Western Blot 2-5 ug/ml
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Application Notes |
In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size. |
Publications |
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Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
PBS and 0.05% BSA |
Preservative |
0.02% Sodium Azide |
Concentration |
1 mg/ml |
Purity |
Immunogen affinity purified |
Alternate Names for Transglutaminase 2/TGM2 Antibody
Background
Transglutaminase 2 is historically a member of the transglutaminase family that catalyzes a calcium-dependent acyl transfer reaction between peptide bound glutamine and a suitable primary amine.The protein is known to participate in all-trans-retinoic acid mediated signaling events as a G-protein and transamidate targets such as RhoA and the retinoblastoma gene product. The action of transglutaminase 2 stabilizes proteins by conferring mechanical resistance and protection from proteolysis. The protein is expressed intracellularly and secreted on the cell surface where it interacts with proteins in the extracellular matrix and aids in anchoring cells to basement membranes. Recently, transglutaminase 2 has been identified as an important factor that interacts with fibronectin in the extracellular matrix at the cell membrane and provides survival signals and inhibits anoikis in fibroblasts. The protein is expressed in human endothelial cells. The human transglutaminase 2 gene is localized in the chromosomal region 20q12. Transcript variants encoding two different isoforms have been found for this gene. Deficiency of the protein results in early-onset diabetes type 2.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Publications for Transglutaminase 2/TGM2 Antibody (NBP2-24470)(1)
Showing Publication 1 -
1 of 1.
Publication using NBP2-24470 |
Applications |
Species |
Anjali A. Satoskar, John P. Shapiro, Mikayla Jones, Cherri Bott, Samir V. Parikh, Sergey V. Brodsky, Lianbo Yu, Haikady N. Nagaraja, Daniel W. Wilkey, Michael L. Merchant, Jon B. Klein, Tibor Nadasdy, Brad H. Rovin Differentiating Staphylococcus infection-associated glomerulonephritis and primary IgA nephropathy: a mass spectrometry-based exploratory study Scientific Reports 2020-10-14 [PMID: 33057112] |
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Secondary Antibodies
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Isotype Controls
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