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TIMP-1 Antibody (151624)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clone
151624
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB9801-SP
Carrier Free
MAB9801-500
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TIMP-1 Antibody (151624) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TIMP-1
Cys25-Arg205
Accession # P12032
Specificity
Detects mouse TIMP-1 in direct ELISAs and Western blots. Shows 100% cross-reactivity with recombinant rat TIMP‑1 and 20% cross-reactivity with recombinant human TIMP-1.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TIMP1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB9801 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TIMP-1 Antibody (151624)

  • CLGI
  • Collagenase inhibitor
  • collagenase inhibitor)
  • EPATIMP-1
  • EPO
  • erythroid potentiating activity
  • Erythroid-potentiating activity
  • Fibroblast collagenase inhibitor
  • FLJ90373
  • HCI
  • metalloproteinase inhibitor 1
  • TIMP metallopeptidase inhibitor 1
  • TIMP1
  • TIMP-1
  • TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
  • Tissue inhibitor of metalloproteinases 1

Background

Tissue inhibitors of metalloproteinases or TIMPs are a family of homologous proteins that regulate the activity of matrix metalloproteinases (MMPs) (1, 2). There are four known members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 that have been found to exhibit multiple functions, including inhibition of active MMPs, pro-MMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis, and the induction of apoptosis. Structurally, TIMPs have two domains, an N‑terminal domain and a C-terminal domain. Each domain consists of three disulfide-bonded loops. TIMP-1 is a glycoprotein produced by a wide range of cell types. Through its N-terminal domain, TIMP-1 inhibits active MMPs by forming a non-covalent binary complex with the MMP active site. The C-terminal domain of TIMP-1 interacts with the C-terminal domain of pro-MMP-9, which may play a role in regulating pro-MMP-9 activation.

  1. Murphy, G. and F. Willenbrock (1995) Methods Enzymol. 248:496.
  2. Brew, K. et al. (2000) Biochim. Biophys. Acta 1477:267.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TIMP-1 Antibody
(151624)
MAB9801
TIMP-1 Antibody (151624)
Species: Mu
Applications: WB

Publications for TIMP-1 Antibody (MAB9801)(5)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, N/A.

We have publications tested in 1 application: Western Blot.


Filter By Application
Western Blot
(4)
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Human
(1)
Mouse
(1)
Rat
(1)
N/A
(1)
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Showing Publications 1 - 5 of 5.
Publications using MAB9801 Applications Species
M Valussi, J Besser, K Wystub-Lis, S Zukunft, M Richter, T Kubin, T Boettger, T Braun Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart Science Advances, 2021-10-13;7(42):eabi6648. 2021-10-13 [PMID: 34644107] (Western Blot, Rat) Western Blot Rat
D Lu, Y Liao, SH Zhu, QC Chen, DM Xie, JJ Liao, X Feng, MH Jiang, W He Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction Stem Cell Res Ther, 2019-04-27;10(1):127. 2019-04-27 [PMID: 31029167] (Western Blot, N/A) Western Blot N/A
JM Adrian-Seg, K Sreenivasa, P Gajawada, H Lörchner, T Braun, J Pöling The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice J. Biol. Chem., 2018-10-29;0(0):. 2018-10-29 [PMID: 30373773] (Western Blot, Human) Western Blot Human
Takeshi Umazume, William M. Thomas, Sabrina Campbell, Hema Aluri, Suharika Thotakura, Driss Zoukhri et al. Lacrimal Gland Inflammation Deregulates Extracellular Matrix Remodeling and Alters Molecular Signature of Epithelial Stem/Progenitor Cells Investigative Opthalmology & Visual Science 2016-01-10 [PMID: 26747770]
Davidsen ML, Wurtz SØ, Romer MU, Sorensen NM, Johansen SK, Christensen IJ, Larsen JK, Offenberg H, Brunner N, Lademann U TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis. Br. J. Cancer, 2006-10-23;95(8):1114-20. 2006-10-23 [PMID: 17047657] (Western Blot, Mouse) Western Blot Mouse

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Bioinformatics

Gene Symbol TIMP1
Uniprot