TFEB Antibody (S1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 7 of 7.

Publications using H00007942-M01	Applications	Species
Wang H, Wang R, Xu S, Lakshmana MK. Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains. Neurosci J 2016-06-07 [PMID: 27433468]
Wang H, Wang R, Carrera I et al. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. eNeuro 2016-05-06 [PMID: 27257626]
Ju X, Yan Y, Liu Q et al. Neuraminidase of influenza A virus binds LAMPs directly and induces lysosome rupture. J Virol. 2015-08-05 [PMID: 26246576]
Wang H, Wang R, Carrera I et al. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory deficits. Eneuro May 6 2016
Lee SJ, Kim YA, Park KK Anti-Fibrotic Effect of Synthetic Noncoding Decoy ODNs for TFEB in an Animal Model of Chronic Kidney Disease International journal of molecular sciences 2022-07-23 [PMID: 35897713] (IHC-P, Mouse)	IHC-P	Mouse
Sun J, Li Y, Yang X et al. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy Aging cell 2021-12-14 [PMID: 34905649] (WB, Mouse)	WB	Mouse
Rockfield S, Guergues J, Rehman N et al. Proteomic Profiling of Iron-Treated Ovarian Cells Identifies AKT Activation, which Modulates the CLEAR Network. Proteomics 2018-09-28 [PMID: 30267477]

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	Simple Western	Rat	08/18/2017	View Summary Application Simple Western Sample Tested cell line, whole cell lysate Species Rat Lot G5031-S1

Array H00007942-M01

• TFEB Antibodies
• TFEB Lysate
• TFEB Protein