TFEB Products

Description

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta

Bioinformatics

Entrez	21425 Mouse 316214 Rat 7942 Human
Uniprot	AAH32448 Human NM_007162 Human NP_009093 Human P19484 Human
Product By Gene ID	7942
Alternate Names	ALPHATFEB BHLHE35 Class E basic helix-loop-helix protein 35 T-cell transcription factor EB TCFEBbHLHe35 transcription factor EB

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