TFEB Antibody (954604) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Transcription Factor EB/TFEB binds E-box (5'-CANNTG-3') where it plays a role in T cell activation through expression of CD40L and CLEAR-box (5'-GTCACGTGAC-3') sequences where it promotes expression of lysosomal genes essential for regulation of autophagy.  TFEB is localized to the cytoplasm and translocates to the nucleus under aberrant lysosomal storage conditions. Phosphorylation of S211 in an MTORC1 dependent manner sequesters TFEB in the cytoplasm through association with 14-3-3 family proteins. Inhibition of MTORC1 causes dissociation from this complex and rapid accumulation in the nucleus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC.

Showing Publications 1 - 3 of 3.

Publications using MAB9170	Applications	Species
Yunyun Fang, Linlin Ji, Chaoyu Zhu, Yuanyuan Xiao, Jingjing Zhang, Junxi Lu et al. Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway Frontiers in Cell and Developmental Biology 11/27/2020 [PMID: 33330497]
Y Wang, H Zhao, X Li, Q Wang, M Yan, H Zhang, T Zhao, N Zhang, P Zhang, L Peng, P Li Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy J. Nutr. Biochem., 2019-07-25;73(0):108214. 2019-07-25 [PMID: 31520816] (ICC, Human)	ICC	Human
K Gkirtziman, E Kabrani, D Nikoleri, A Polyzos, A Blanas, P Sidiropoul, A Makrigiann, G Bertsias, DT Boumpas, P Verginis IFN? Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion Cell Rep, 2018-10-23;25(4):921-933.e5. 2018-10-23 [PMID: 30355498] (ICC, Human)	ICC	Human

Array MAB9170

• TFEB Antibodies
• TFEB Lysate