Human peripheral blood lymphocytes were stained with Mouse Anti-Human TACI/TNFRSF13B APC-conjugated Monoclonal Antibody (Catalog # FAB1741A) and Mouse Anti-Human CD19 Fluorescein-conjugated Monoclonal Antibody (Catalog ...read more
Raji human Burkitt's lymphoma cell line was stained with Mouse Anti-Human TACI/TNFRSF13B APC-conjugated Monoclonal Antibody (Catalog # FAB1741A, filled histogram) or isotype control antibody (Catalog # IC002A, open ...read more
Clone 165604 was used by HLDA to establish CD designation
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TACI/TNFRSF13B Ser2-Thr166 Accession # O14836
Specificity
Detects human TACI/TNFRSF13B in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human BCMA or recombinant mouse TACI is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF13B
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for TACI/TNFRSF13B/CVID Antibody (165604) [Allophycocyanin]
CD267 antigen
CD267
CVID
CVID2
FLJ39942
MGC133214
TACI
TACIMGC39952
TNFRSF13B
TNFRSF14B
Transmembrane activator and CAML interactor
tumor necrosis factor receptor 13B
tumor necrosis factor receptor superfamily member 13B
tumor necrosis factor receptor superfamily, member 13B
Background
TACI, transmembrane activator and CAML-interactor, is a member of the TNF receptor superfamily. TACI is a type III membrane protein with an extracellular N‑terminus in the absence of a cleaved signal sequence. The extracellular region of TACI contains two cysteine rich domains. Within the TNFRSF, it shares the highest homology with BCMA. TACI and BCMA have both been shown to bind APRIL and BAFF, members of the TNF ligand superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Analogous to BCMA, data suggests that TACI may play an important role in B cell development, function and regulation. Human TACI is a 293 amino acid (aa) protein consisting of a 166 aa extracellular domain, a 20 aa transmembrane domain, and a 107 aa intracellular domain. Human and mouse TACI share 54% amino acid identity.
Xia, X.-Z. et al. (2000) J. Exp. Med. 192:137.
von Bulow, G.U. et al. (1997) Science, 278:138.
Gross, J.A. et al. (2000) Nature 404:995.
Marsters, S.A. et al. (2000) Curr. Biol. 10:785.
Yan, M. et al. (2000) Nature Immunol. 1:37.
Wu, Y. et al. (2000) J. Biol. Chem. 275:35478.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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