Western Blot: SUB1 Antibody [NB100-59774] - Detection of Human PC4 on HeLa whole cell lysate using NB100-59774.
Immunohistochemistry-Paraffin: SUB1 Antibody [NB100-59774] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- PC4 used at a dilution of 1:200 (1ug/ml). Detection: DAB
The immunogen recognized by this antibody maps to a region between residue 25 and 75 of human positive cofactor 4 using the numbering given in entry NP_006704.2 (GeneID 10923).
Predicted Species
Orangutan (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SUB1
Purity
Immunogen affinity purified
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Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections. Use in chromatin immunoprecipitation reported in scientific literature (PMID: 30992017).
activated RNA polymerase II transcription cofactor 4
activated RNA polymerase II transcriptional coactivator p15
MGC102747
p15
PC4p14P15
Positive cofactor 4
RPO2TC1
SUB1 homolog (S. cerevisiae)
SUB1 homolog
Background
PC4 is a multifunctional transcriptional coactivator that plays an important role in transcription, repair, and replication. PC4 interacts with general transcription factors, DNA repair factors, and mRNA processing factors to influence transcription initiation, coactivation, polyadenylation, transcription termination, and transcriptional repression. PC4 has been demonstrated to be a DNA binding protein and a bona fide component of chromatin with chromatin-compacting ability.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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