Striatin Antibody

Striatin (STRN) is a calmodulin-binding member of WD-repeat family of proteins/WD repeat striatin family and is an intracellular protein localized mainly in cytoplasm as well as in cellular membranes as peripheral membrane protein, and is mostly present in neurons of mammalian basal ganglia and cranial/spinal motor nuclei. Striatin's protein-protein interaction domains include caveolin-binding (amino acids 55-63), coiled-coil (amino acids 70-116), Ca2+-calmodulin-binding (amino acids 149-166), and a series of eight WD repeat (amino acids 419-780) motifs. Striatin is a scaffolding protein which functions in a calcium dependent fashion and is implicated in cellular signaling and trafficking processes. Striatin forms complex with PP2A (protein phosphatase 2A) which associates directly to and controls the function of ER-alpha. Moreover, striatin targets ER-alpha to the cell membrane and serves as a scaffold for the assembly of proteins essential to rapid, estrogen-induced eNOS activation. Striatin has also been suggested as a candidate gene for human ARVC (arrhythmogenic right ventricular cardiomyopathy), familial cardiac disease characterized by ventricular arrhythmias and sudden cardiac death.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC/IF, IP, WB, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using NB110-74571	Applications	Species
Montalbano AP, Hawgood S, Mendelson CR. Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes. Endocrinology 2013-01-01 [PMID: 23183169] (Mouse)		Mouse
Chen YK, Chen CY, Hu HT, Hsueh YP. CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex Mol Biol Cell 2012-11-01 [PMID: 23015759] (WB, ICC/IF, Rat)	WB, ICC/IF	Rat
Cull J, Cooper S, Alharbi H et al. Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in micein vivo bioRxiv 2023-10-25 (Western Blot, Human)	Western Blot	Human
Joshua J. Cull, Susanna T.E. Cooper, Hajed O. Alharbi, Sonia P. Chothani, Owen J.L. Rackham, Daniel N. Meijles, Philip R. Dash, Risto Kerkelä, Neil Ruparelia, Peter H. Sugden, Angela Clerk Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo Clinical Science (London, England : 1979) 2024-05-01 [PMID: 38718356]
Moreno, CS et al. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. J Biol Chem;276(26):24253-60. 2001-06-29 [PMID: 11319234] (IP, ICC/IF, Human)	IP, ICC/IF	Human
Yu, XX et al. Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol Biol Cell;12(1):185-99. 2001-01-01 [PMID: 11160832] (IP)	IP
Moreno, CS et al. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J Biol Chem;275(8):5257-63. 2000-02-25 [PMID: 10681496] (IP, Human)	IP	Human

Array NB110-74571

• Striatin Antibodies
• Striatin Lysate
• Striatin Protein