MST3 Antibody

The growth of axons is fundamental to the development and repair of brain circuitry. It has been shown that Mst3, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3 is activated in response to trophic factors, and suppressing its expression or its function blocks axon outgrowth (1). Mst3 has been recently demonstrated to undergo a caspase-mediated cleavage during apoptosis. The proteolytic cleavage of the C-terminus of Mst3 caused nuclear translocation of its kinase domain. Mst3 contains both nuclear localization sequence (NLS) and NES signals, which may cooperate to control the subcellular distribution of Mst3 (2). In situ hybridization of rat brain sections indicated that MST3b is widely expressed in different brain regions, with especially high expression in hippocampus and cerebral cortex. When expressed in human embryonic kidney 293 (HEK293) cells, MST3b effectively phosphorylated myelin basic protein, as well as undergoing autophosphorylation (3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-87833	Applications	Species
Donnarumma E, Bhushan S, Bradley JM et al. Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2)-Dependent Signaling in Chronic Heart Failure. J Am Heart Assoc. 2016-07-30 [PMID: 27473036] (WB, Mouse)	WB	Mouse
Tain Y, Lee C, Chan JY, Hsu C. Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal NG-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring Am J Obstet Gynecol. 2016-07-22 [PMID: 27457113] (WB)	WB

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Russ Tas	ELISA	Human	11/12/2021	View Summary Application ELISA Sample Tested SH-SY5Y cell lsyate Species Human Lot 14274 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.***

Array NBP1-87833

• MST3 Antibodies
• MST3 Lysate
• MST3 Proteins