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STAT6 [p Tyr641] Antibody (1248D) [Phycoerythrin]

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Human peripheral blood mononuclear cells (PBMCs) either (A) Th2-stimulated or (B) unstimulated were stained with Rabbit Anti-Human Phospho-STAT6 (Y641) PE-conjugated Monoclonal Antibody (Catalog # IC37173P) and Mouse Anti-Human CD4 APC-conjugated Monoclonal Antibody (Catalog # FAB3791A). Quadrant markers were set based on control antibody staining (Catalog # IC1051P). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with methanol. View our protocol for Staining Intracellular Molecules.
Human peripheral blood mononuclear cells (PBMCs) either (A) Th2-stimulated or (B) unstimulated were stained with Rabbit Anti-Human Phospho-STAT6 (Y641) PE-conjugated Monoclonal Antibody (Catalog # IC37173P) and Mouse ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
1248D
Clonality
Monoclonal
Host
Rabbit
Conjugate
Phycoerythrin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC3717U-100UG
Alexa Fluor 405
IC3717V-100UG
Alexa Fluor 488
IC3717G-100UG
Alexa Fluor 594
IC3717T-100UG
Alexa Fluor 700
IC3717N-100UG
Alexa Fluor 750
IC3717S-100UG
Unconjugated
MAB3717
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB3717
Carrier Free
MAB3717
Carrier Free
MAB3717-SP
Carrier Free
IC3717V-100UG
Carrier Free
IC3717U-100UG
Carrier Free
IC3717T-100UG
Carrier Free
IC3717S-100UG
Carrier Free
IC3717G-100UG
Carrier Free
IC3717N-100UG
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STAT6 [p Tyr641] Antibody (1248D) [Phycoerythrin] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Phosphopeptide containing human STAT6 Y641 site.
Accession # P42226
Modification
p Tyr641
Specificity
Detects human STAT6 when phosphorylated at Y641.
Details of Functionality
None<br /><br />
Source
N/A
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for STAT6 [p Tyr641] Antibody (1248D) [Phycoerythrin]

  • D12S1644
  • EC 2.4.1.227
  • EC 2.7.7.6
  • IL-4 Stat
  • IL-4-STAT
  • signal transducer and activator of transcription 6
  • signal transducer and activator of transcription 6, interleukin-4 induced
  • STAT, interleukin-4 induced
  • STAT, interleukin4-induced
  • STAT6
  • STAT6B
  • STAT6C
  • transcription factor IL-4 STAT

Background

Signal Transducer and Activator of Transcription 6 (STAT6) mediates the signaling of cytokines such as IL-4 and IL-13. STAT6 acts as a signal transducer in the cytoplasm and, upon phosphorylation at Y641, translocates to the nucleus and binds to the DNA consensus site TTCN4GAA. Knockout studies in mice suggest that STAT6 functions in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Isotype Controls

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