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StAR Antibody (STAR/2140) [DyLight 594]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, MA
Clone
STAR/2140
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 594

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-75740AF350
Alexa Fluor 405
NBP2-75740AF405
Alexa Fluor 488
NBP2-75740AF488
Alexa Fluor 532
NBP2-75740AF532
Alexa Fluor 594
NBP2-75740AF594
Alexa Fluor 647
NBP2-75740AF647
Alexa Fluor 700
NBP2-75740AF700
Alexa Fluor 750
NBP2-75740AF750
Allophycocyanin
NBP2-75740APC
Biotin
NBP2-75740B
CoraFluor 1
NBP2-75740CL1
DyLight 350
NBP2-75740UV
DyLight 405
NBP2-75740V
DyLight 488
NBP2-75740G
DyLight 550
NBP2-75740R
DyLight 650
NBP2-75740C
DyLight 680
NBP2-75740FR
DyLight 755
NBP2-75740IR
FITC
NBP2-75740F
HRP
NBP2-75740H
Janelia Fluor 525
NBP2-75740JF525
Janelia Fluor 549
NBP2-75740JF549
Janelia Fluor 646
NBP2-75740JF646
Janelia Fluor 669
NBP2-75740JF669
PE
NBP2-75740PE
PerCP
NBP2-75740PCP
Unconjugated
NBP2-75739-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-75739-100ug
Azide and BSA Free
NBP2-75740
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StAR Antibody (STAR/2140) [DyLight 594] Summary

Immunogen
Recombinant fragment (around aa 39-108) of human StAR protein (exact sequence is proprietary) (Uniprot: P49675)
Localization
Cytoplasmic (Mitochondria)
Marker
Leydig Cell Marker
Specificity
Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
STAR
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Protein Array
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for StAR Antibody (STAR/2140) [DyLight 594]

  • cholesterol trafficker
  • mitochondrial steroid acute regulatory protein
  • StAR
  • StARD1
  • STARD1StAR-related lipid transfer (START) domain containing 1
  • START domain containing 1
  • START domain-containing protein 1
  • steroid acute regulatory protein
  • steroidogenic acute regulator
  • steroidogenic acute regulatory protein
  • steroidogenic acute regulatory protein, mitochondrial

Background

StAR is encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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StAR Antibody
(STAR/2140) [DyLight
NBP2-75740DL594
StAR Antibody (STAR/2140) [DyLight 594]
Species: Hu
Applications: IHC, MA

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Bioinformatics

Gene Symbol STAR