ST6 GalNAc alpha-2,6-sialyltransferaseV/ST6GALNAC5 Antibody (719508) Summary
Immunogen |
Chinese hamster ovary cell line CHO-derived recombinant human SGalNAc alpha -2,6-sialyltransferase V/ST6GALNAC5 Gly30-Phe336 Accession # Q9BVH7 |
Specificity |
Detects human GalNAc alpha -2,6-sialyltransferase V/ST6GALNAC5 in direct ELISAs. In direct ELISAs, no cross-reactivity
with recombinant human (rh) ST6GALNAC4 or rhST6GALNAC6 is observed. |
Source |
N/A |
Isotype |
IgG2a |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
ST6GALNAC5 |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunocytochemistry 8-25 ug/mL
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Publications |
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Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative |
No Preservative |
Concentration |
LYOPH |
Reconstitution Instructions |
Sterile PBS to a final concentration of 0.5 mg/mL. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for ST6 GalNAc alpha-2,6-sialyltransferaseV/ST6GALNAC5 Antibody (719508)
Background
Gangliosides are acidic glycosphingolipids that contain one or more sialic acid residues (1). They are abundant in the nervous system, where they play crucial modulatory roles in cellular recognition, interaction, adhesion, and signal transduction, particularly during early developmental stages. The expression of gangliosides in the nervous system is developmentally regulated through various sialyltransferases (2). ST6GALNAC5 is a sialyltransferase involved in the biosynthesis of ganglioside GD1a (NeuAc alpha 2,3Gal beta 1,3GalNAc beta 1,4(NeuAc alpha 2,3)Gal beta 1,4Glc beta 1-Cer) from GM1b (NeuAc alpha 2,3Gal beta 1,3GalNAc beta 1,4Gal beta 1,4Glc beta 1-Cer), and its expression is restricted to the brain (3, 4). ST6GALNAC5 has been identified as a key player in the metastasis of breast cancer cells to the brain by potentially enabling the cancer cells to cross the blood-brain barrier (5, 6). The recombinant ST6GALNAC5 was active on fetuin from fetal calf serum when assayed using a phosphatase-coupled method (7) suggesting the substrate specificity of ST6GALNAC5 may require further characterization.
- Kolter, T. et al. (2002) J. Biol. Chem. 277:25859.
- Yu, R.K. et al. (2008) Glycoscience DOI: 10.1007/978-3-540-30429-6_41.
- Okajima, T. et al. (1999) J. Biol. Chem.274:30557.
- Harduin-Lepers, A. et al. (2005) Glycobiology 15:805.
- Bos, P.D. et al. (2009) Nature 459:1005.
- Arshad, F. et al. (2011). Patholog. Res. Int. DOI: 10.4061/2011/920509.
- Wu, Z.L. et al. (2010) Glycobiology DOI: 10.1093/glycob/cwq187.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for ST6 GalNAc alpha-2,6-sialyltransferaseV/ST6GALNAC5 Antibody (MAB67151) (0)
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