ST2/IL-33R Antibody [Allophycocyanin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ST2, also known as IL-33R, IL-1 R4 and T1, is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses (1, 2). Human ST2 consists of a 310 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 207 aa cytoplasmic domain with an intracellular TIR domain (3, 4). Alternate splicing of the 120 kDa human ST2 generates a soluble 60 kDa isoform that lacks the transmembrane and cytoplasmic regions as well as an isoform that additionally lacks the third Ig‑like domain (4). Within the ECD, human ST2 shares 68% and 64% aa sequence identity with mouse and rat ST2, respectively. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes (5‑8). It binds IL-33, a cytokine that is upregulated by inflammation or mechanical strain in smooth muscle cells, airway epithelia, keratinocytes, and cardiac fibroblasts (5, 9). IL-33 binding induces the association of ST2 with IL-1R AcP, a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2 (1, 10, 11). In macrophages, ST2 interferes with signaling from IL-1 RI and TLR4 by sequestering the adaptor proteins MyD88 and Mal (7). In addition to its role in promoting mast cell and Th2 dependent inflammation, ST2 activation enhances antigen induced hypernociception and protects from atherosclerosis and cardiac hypertrophy (5, 12‑14). The soluble ST2 isoform is released by activated Th2 cells and strained cardiac myocytes and is elevated in the serum in allergic asthma (6, 8, 15). Soluble ST2 functions as a decoy receptor that blocks IL‑33's ability to signal through transmembrane ST2 (10, 13‑15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 6 of 6.

Publications using FAB5231A	Applications	Species
GM Jowett, E Read, LB Roberts, D Coman, M Vilà Gonzá, T Zabinski, U Niazi, R Reis, TJ Trieu, D Danovi, E Gentleman, L Vallier, MA Curtis, GM Lord, JF Neves Organoids capture tissue-specific innate lymphoid cell development in mice and humans Cell Reports, 2022-08-30;40(9):111281. 2022-08-30 [PMID: 36044863] (Flow Cytometry, Human)	Flow Cytometry	Human
YQ Peng, DH Chen, ZB Xu, SB Fang, BX He, XQ Liu, CA Akdis, QL Fu IL-33 receptor expression on myeloid and plasmacytoid dendritic cells after allergen challenge in patients with allergic rhinitis International immunopharmacology, 2021-10-12;101(0):108233. 2021-10-12 [PMID: 34653730] (Flow Cytometry, Human)	Flow Cytometry	Human
E Cho, B Theall, J Stampley, J Granger, NM Johannsen, BA Irving, G Spielmann Cytomegalovirus Infection Impairs the Mobilization of Tissue-Resident Innate Lymphoid Cells into the Peripheral Blood Compartment in Response to Acute Exercise Viruses, 2021-08-03;13(8):. 2021-08-03 [PMID: 34452400] (Flow Cytometry, Human)	Flow Cytometry	Human
M Paplinska-, P Misiukiewi, M Proboszcz, P Nejman-Gry, K Gorska, R Krenke The Expressions of TSLP, IL-33, and IL-17A in Monocyte Derived Dendritic Cells from Asthma and COPD Patients are Related to Epithelial-Macrophage Interactions Cells, 2020-08-22;9(9):. 2020-08-22 [PMID: 32842623] (Flow Cytometry, Human)	Flow Cytometry	Human
O Goovaerts, M Massinga-L, P Ondoa, A Ceulemans, W Worodria, H Mayanja-Ki, R Colebunder, L Kestens Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS PLoS ONE, 2019-04-25;14(4):e0215991. 2019-04-25 [PMID: 31022273] (Flow Cytometry, Human)	Flow Cytometry	Human
XH Wang, W Liu, DX Fan, WT Hu, MQ Li, XY Zhu, LP Jin IL?33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrin ?4?1 and CD62L Mol Med Rep, 2017-07-26;0(0):. 2017-07-26 [PMID: 28765940] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB5231A

• ST2/IL-33R Antibodies
• ST2/IL-33R Antibody Pair
• ST2/IL-33R ELISA Kit
• ST2/IL-33R Proteins
• ST2/IL-33R ELISAs
• ST2/IL-33R Proteins and Enzymes