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SLC6A2/NET/Noradrenaline transporter Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: SLC6A2/NET/Noradrenaline transporter Antibody [NBP2-62704] - Analysis in human adrenal gland and pancreas tissues using Anti-SLC6A2 antibody. Corresponding ...read more
Immunohistochemistry-Paraffin: SLC6A2/NET/Noradrenaline transporter Antibody [NBP2-62704] - Staining of human adrenal gland shows high expression.
Immunohistochemistry-Paraffin: SLC6A2/NET/Noradrenaline transporter Antibody [NBP2-62704] - Staining of human pancreas shows low expression as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

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SLC6A2/NET/Noradrenaline transporter Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLA
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLC6A2
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:2500 - 1:5000
  • Immunohistochemistry-Paraffin 1:2500 - 1:5000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
SLC6A2/NET/Noradrenaline transporter Recombinant Protein Antigen (NBP2-62704PEP)
Publications
Read Publications using
NBP2-62704 in the following applications:

  • 1 publication
  • WB
    1 publication

Reactivity Notes

Mouse (85%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for SLC6A2/NET/Noradrenaline transporter Antibody

  • NAT1
  • NAT1neurotransmitter transporter
  • NET
  • NET1sodium-dependent noradrenaline transporter
  • Noradrenalin Transporter
  • Norepinephrine Transporter
  • SLC6A2
  • SLC6A5
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • Solute carrier family 6 member 2
  • solute carrier family 6 member 5

Background

Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SLC6A2/NET/Noradrenaline transporter Antibody (NBP2-62704)(2)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, WB.


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IHC-P
(1)
WB
(1)
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Bioinformatics

Gene Symbol SLC6A2