Orthogonal Strategies: Immunohistochemistry-Paraffin: SLC6A2/NET/Noradrenaline transporter Antibody [NBP2-62704] - Analysis in human adrenal gland and pancreas tissues using Anti-SLC6A2 antibody. Corresponding ...read more
Immunohistochemistry-Paraffin: SLC6A2/NET/Noradrenaline transporter Antibody [NBP2-62704] - Staining of human adrenal gland shows high expression.
Immunohistochemistry-Paraffin: SLC6A2/NET/Noradrenaline transporter Antibody [NBP2-62704] - Staining of human pancreas shows low expression as expected.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified
Alternate Names for SLC6A2/NET/Noradrenaline transporter Antibody
NAT1
NAT1neurotransmitter transporter
NET
NET1sodium-dependent noradrenaline transporter
Noradrenalin Transporter
Norepinephrine Transporter
SLC6A2
SLC6A5
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Solute carrier family 6 member 2
solute carrier family 6 member 5
Background
Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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