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Siglec-8 Antibody

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Western Blot: SIGLEC8 Antibody [NBP2-20361] - Sample (30 ug of whole cell lysate) A: THP-1 10% SDS PAGE gel, diluted at 1:1000.
Western Blot: SIGLEC8 Antibody [NBP2-20361] - Sample (30 ug of whole cell lysate) A: THP-1 10% SDS PAGE gel, diluted at 1:1000.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Siglec-8 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human Siglec-8. The exact sequence is proprietary.
Localization
Membrane; Single-pass type I membrane protein
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SIGLEC8
Purity
Antigen Affinity-purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
Theoretical MW
54 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7), 0.1M Glycine, 20% Glycerol
Preservative
0.01% Thimerosal
Purity
Antigen Affinity-purified

Alternate Names for Siglec-8 Antibody

  • CD329 antigen
  • CDw329
  • MGC59785
  • SAF2
  • SAF2SAF-2
  • sialic acid binding Ig-like lectin 8
  • Sialoadhesin family member 2
  • Siglec8
  • Siglec-8
  • SIGLEC8L
  • SIGLEC8Lsialic acid-binding Ig-like lectin 8

Background

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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Bioinformatics

Gene Symbol SIGLEC8
Uniprot