SHFM3 Antibody Summary
Immunogen |
Synthetic peptide taken within amino acid region 240-290 on human FBX4 protein. |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
FBXW4 |
Purity |
Affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Dot Blot 1:4000
- ELISA 1:4000
- Immunoprecipitation 1:150
- Western Blot 1:500
|
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary). |
Preservative |
0.02% Sodium Azide |
Purity |
Affinity purified |
Alternate Names for SHFM3 Antibody
Background
SHFM3 is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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