DACH1 Antibody Summary
Immunogen |
Amino acids 474-501 of human Dach1 were used as the immunogen. |
Predicted Species |
Monkey (100%), Xenopus (94%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
DACH1 |
Purity |
Protein A purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry
- Immunohistochemistry-Paraffin 5ug/ml
- Western Blot 5-7ug/ml~
|
Reactivity Notes
The amino acid sequence used as immunogen is 83% homologous in Zebrafish.
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
0.2 ml PBS and 0.05% BSA |
Preservative |
0.05% Sodium Azide |
Concentration |
0.5 mg/ml |
Purity |
Protein A purified |
Alternate Names for DACH1 Antibody
Background
Dachshund homolog 1 belongs to the DACH/Dachshund family. It is a transcription factor involved in the regulation of organogenesis. DACH1 plays a role in retinal and pituitary precursor cell proliferation. It is reported to be expressed in breast cancer cell lines and to inhibit transforming growth factor-beta (TGF-beta)-induced apoptosis. DACH1 repressed TGF-beta induction of AP-1 and Smad signaling in gene reporter assays and repressed endogenous TGF-beta-responsive genes by microarray analyses. DACH1 participates in the negative regulation of TGF-beta signaling by interacting with NCoR and Smad4. Mouse DACH1 protein was immunolocalized to specific cell types within the developing kidneys, eyes, cochleae, and limb buds.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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