SF3B4 Antibody (3A1)

SF3B4 (splicing factor 3B subunit 4, also known as SF3b50 or SAP49), is a ubiquitously expressed nuclear protein which forms a subunit of splicing factor SF3B (SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125) required for 'A' complex assembly formed by the stable binding of U2 snRNP to pre-mRNA's BPS (branchpoint sequence). SF3B4 interacts directly with SF3B2 and also forms a component of U11/U12 snRNPs that are a part of the U12-type spliceosome. SF3B4 has also been suggested to implicate in 'E' complex assembly and is also found in 'B' and 'C' complexes. SF3B4 is also associated with minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Defects in SF3B4 have been linked to AFD1 (acrofacial dysostosis type 1) which is a form of acrofacial dysostosis, a group of disorders characterized by malformation of the craniofacial skeleton and limbs.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 2 of 2.

Publications using NBP1-92692	Applications	Species
Yang G, Xiang J, Yang X et al. Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2 eLife 2024-11-04 [PMID: 39495216]
Sikorski K, Mehta A et al. A high-throughput pipeline for validation of antibodies. Nat Methods 2018-01-11 [PMID: 30377371] (Human) Details: Antibody validation based on denaturing gel electrophoresis of biotinylated cell lysates (PAGE) followed by mass spectrometry (MS) and antibody array analysis (MAP).		Human

Array NBP1-92692

• SF3B4 Antibodies
• SF3B4 Proteins