Serum Amyloid A1/A2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mouse serum amyloid A protein-1 (SAA1) is a multifunctional apolipoprotein produced by hepatocytes in response to pro-inflammatory cytokines. It is secreted as a 12 kDa, 103 amino acid (aa), nonglycosylated polypeptide and circulates as part of the HDL complex. The SAA1 gene is one of three SAA genes in mouse, and, based on human, is likely to be allelic. The SAA1 gene product differs from the SAA2 gene product by only nine amino acids. In human, circulating SAA1 shows multiple proteolytically-generated isoforms, with anywhere from one to three amino acids being cleaved from either the N- or C-terminus. The same situation may exist in mouse. The amino acid sequence of mature mouse SAA1 is 72%, 72%, 67%, and 74% identical to mature human, rabbit, equine, and hamster SAA1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: Cell Culture, ELISA Development, ICC, IHC, IHC-P, In vivo assay, Neutralization, Western Blot.

Showing Publications 1 - 10 of 37. Show All 37 Publications. Collapse Publications.

Publications using AF2948	Applications	Species
Holcomb, M;Marshall, A;Flinn, H;Lozano, M;Soriano, S;Gomez-Pinilla, F;Treangen, TJ;Villapol, S; Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice Research square 2024-04-02 [PMID: 38645104] (Western Blot, Mouse)	Western Blot	Mouse
He, M;Liu, Y;Chen, S;Deng, H;Feng, C;Qiao, S;Chen, Q;Hu, Y;Chen, H;Wang, X;Jiang, X;Xia, X;Zhao, M;Lyu, N; Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma Nature communications 2024-02-26 [PMID: 38409200] (In vivo assay, Mouse)	In vivo assay	Mouse
Yu, J;Zhu, H;Taheri, S;Lee, JY;Diamond, DM;Kirstein, C;Kindy, MS; Serum amyloid A-dependent inflammasome activation and acute injury in a mouse model of experimental stroke Research square 2023-09-08 [PMID: 37720021] (Western Blot, Mouse)	Western Blot	Mouse
Chenfeng He, Riyo Konishi, Ayano Harata, Yuki Nakamura, Rin Mizuno, Mayuko Yoda et al. Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model Frontiers in Immunology 2/3/2023 [PMID: 36817472]
Vaisar T, Wang S, Omer M et al. 10,12-conjugated linoleic acid supplementation improves HDL composition and function in mice Journal of lipid research 6/14/2022 [PMID: 35714730]
S Soriano, K Curry, Q Wang, E Chow, TJ Treangen, S Villapol Fecal Microbiota Transplantation Derived from Alzheimer's Disease Mice Worsens Brain Trauma Outcomes in Wild-Type Controls International Journal of Molecular Sciences, 2022-04-19;23(9):. 2022-04-19 [PMID: 35562867] (Western Blot, Mouse)	Western Blot	Mouse
M Wakai, R Hayashi, Y Ueno, K Onishi, T Takasago, T Uchida, H Takigawa, R Yuge, Y Urabe, S Oka, Y Kitadai, S Tanaka Promoting mechanism of serum amyloid a family expression in mouse intestinal epithelial cells PLoS ONE, 2022-03-18;17(3):e0264836. 2022-03-18 [PMID: 35303008] (IHC, Mouse)	IHC	Mouse
Y Song, S Hu, J Zhang, L Zhu, X Zhao, Q Chen, J Zhang, Y Bai, Y Pan, C Shao Fractionated Irradiation of Right Thorax Induces Abscopal Damage on Bone Marrow Cells via TNF-alpha and SAA International Journal of Molecular Sciences, 2021-09-15;22(18):. 2021-09-15 [PMID: 34576128] (Western Blot, Mouse)	Western Blot	Mouse
V Farré-Alin, A Palomino-A, P Narros-Fer, AB Lopez-Rodr, C Decouty-Pe, A Muñoz-Mont, J Zamorano-F, B Mansilla-F, J Giner-Garc, P García-Fei, M Sáez-Alegr, AJ Palpán-Flo, JM Roda-Frade, CS Carabias, JM Rosa, B Civantos-M, S Yus-Teruel, L Gandía, A Lagares, BJ Hernández-, J Egea Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients Biomedicines, 2021-05-25;9(6):. 2021-05-25 [PMID: 34070533] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
IS Massart, G Paulissen, A Loumaye, P Lause, SA Pötgens, MM Thibaut, E Balan, L Deldicque, A Atfi, E Louis, D Gruson, LB Bindels, MA Meuwis, JP Thissen Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia Cancers (Basel), 2020-10-31;12(11):. 2020-10-31 [PMID: 33142864] (Western Blot, Mouse)	Western Blot	Mouse
S Lim, KR Dunlap, ME Rosa-Caldw, WS Haynie, LT Jansen, TA Washington, NP Greene Comparative plasma proteomics in muscle atrophy during cancer-cachexia and disuse: The search for atrokines Physiol Rep, 2020-10-01;8(19):e14608. 2020-10-01 [PMID: 33063952] (Western Blot, Mouse)	Western Blot	Mouse
CY Han, I Kang, M Omer, S Wang, T Wietecha, TN Wight, A Chait Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its anti-inflammatory properties JCI Insight, 2020-09-24;0(0):. 2020-09-24 [PMID: 32970631] (ICC, IHC, Human, Mouse)	ICC, IHC	Human, Mouse
A Chait, LJ den Hartig, S Wang, L Goodspeed, I Babenko, WA Altemeier, T Vaisar Presence of serum amyloid A3 in mouse plasma is dependent on the nature and extent of the inflammatory stimulus Sci Rep, 2020-06-25;10(1):10397. 2020-06-25 [PMID: 32587356] (Western Blot, Mouse)	Western Blot	Mouse
Xiao-Wen Gan, Wang-Sheng Wang, Jiang-Wen Lu, Li-Jun Ling, Qiong Zhou, Hui-Juan Zhang et al. De novo Synthesis of SAA1 in the Placenta Participates in Parturition Frontiers in Immunology 6/9/2020 [PMID: 32582166]
U Smole, N Gour, J Phelan, G Hofer, C Köhler, B Kratzer, PA Tauber, X Xiao, N Yao, J Dvorak, L Caraballo, L Puerta, S Rosskopf, J Chakir, E Malle, AP Lane, WF Pickl, S Lajoie, M Wills-Karp Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity Nat. Immunol., 2020-06-22;21(7):756-765. 2020-06-22 [PMID: 32572240] (Neutralization, Mouse)	Neutralization	Mouse
Sirena Soriano, Bridget Moffet, Evan Wicker, Sonia Villapol Serum Amyloid A is Expressed in the Brain After Traumatic Brain Injury in a Sex-Dependent Manner Cellular and Molecular Neurobiology 10/1/2020 [PMID: 32060858]
June-Yong Lee, Jason A. Hall, Lina Kroehling, Lin Wu, Tariq Najar, Henry H. Nguyen et al. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease Cell 1/1/2020 [PMID: 31866067]
H Zheng, H Li, J Zhang, H Fan, L Jia, W Ma, S Ma, S Wang, H You, Z Yin, X Li Serum amyloid A exhibits pH dependent antibacterial action and contributes to host defense against Staphylococcus aureus cutaneous infection J. Biol. Chem., 2019-12-09;0(0):. 2019-12-09 [PMID: 31819008] (IHC-P, Western Blot, Mouse)	IHC-P, Western Blot	Mouse
Li Y, Xu Y, Jadhav K et al. Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis Arterioscler. Thromb. Vasc. Biol. 8/1/2019 [PMID: 31291759]
E Wicker, L Benton, K George, W Furlow, S Villapol Serum Amyloid A Protein as a Potential Biomarker for Severity and Acute Outcome in Traumatic Brain Injury Biomed Res Int, 2019-04-16;2019(0):5967816. 2019-04-16 [PMID: 31119176] (Western Blot, Mouse)	Western Blot	Mouse
Lin Zhu, Thao Luu, Christopher H. Emfinger, Bryan A. Parks, Jeanne Shi, Elijah Trefts et al. CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet Diabetes 12/1/2018 [PMID: 30213825]
H Wang, M Blackall, L Sominsky, SJ Spencer, R Vlahos, M Churchill, S Bozinovski Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production J Neuroinflammation, 2018-07-06;15(1):200. 2018-07-06 [PMID: 29980196] (IHC, Mouse)	IHC	Mouse
BH Hinrichs, JD Matthews, D Siuda, MN O'Leary, AA Wolfarth, BJ Saeedi, A Nusrat, AS Neish Serum Amyloid A1 is an epithelial pro-restitutive factor Am. J. Pathol., 2018-01-31;0(0):. 2018-01-31 [PMID: 29366677] (Cell Culture, Human)	Cell Culture	Human
X Li, Y Lyu, J Shen, Y Mu, L Qiang, L Liu, K Araki, BP Imbimbo, KI Yamamura, S Jin, Z Li Amyloid deposition in a mouse model humanized at the transthyretin and retinol-binding protein 4 loci Lab. Invest., 2018-01-12;0(0):. 2018-01-12 [PMID: 29330472] (IHC, Mouse)	IHC	Mouse
Ha Won Kim, Andra L. Blomkalns, Mourad Ogbi, Manesh Thomas, Daniel Gavrila, Bonnie S. Neltner et al. Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine American Journal of Physiology-Heart and Circulatory Physiology 12/1/2017 [PMID: 28971841]
Y Zhang, Y Wei, B Jiang, L Chen, H Bai, X Zhu, X Li, H Zhang, Q Yang, J Ma, Y Xu, J Ben, DC Christiani, Q Chen Scavenger receptor A1 prevents metastasis of non-small cell lung cancer via suppression of macrophage serum amyloid A1 Cancer Res, 2017-02-15;0(0):. 2017-02-15 [PMID: 28202524] (IHC, Human)	IHC	Human
Mayuko Maeda, Tomoaki Murakami, Naeem Muhammad, Yasuo Inoshima, Naotaka Ishiguro Experimental transmission of systemic AA amyloidosis in autoimmune disease and type 2 diabetes mellitus model mice Experimental Animals 11/1/2016 [PMID: 27321428]
Giuseppe Mazza, J. Paul Simons, Raya Al-Shawi, Stephan Ellmerich, Luca Urbani, Sofia Giorgetti et al. Amyloid persistence in decellularized liver: biochemical and histopathological characterization Amyloid 1/2/2016 [PMID: 26646718]
Chang Yeop Han, Chongren Tang, Myriam E. Guevara, Hao Wei, Tomasz Wietecha, Baohai Shao et al. Serum amyloid A impairs the antiinflammatory properties of HDL Journal of Clinical Investigation 12/7/2015 [PMID: 26642365]
Sonia Villapol, Dmitry Kryndushkin, Maria G. Balarezo, Ashley M. Campbell, Juan M. Saavedra, Frank P. Shewmaker et al. Hepatic Expression of Serum Amyloid A1 Is Induced by Traumatic Brain Injury and Modulated by Telmisartan The American Journal of Pathology 10/1/2015 [PMID: 26435412]
Dokyoon Kim, Francesco Marchetti, Zuxiong Chen, Sasa Zaric, Robert J. Wilson, Drew A. Hall et al. Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation Scientific Reports 7/19/2013 [PMID: 23868657]
Andrea Bonetto, Tufan Aydogdu, Noelia Kunzevitzky, Denis C. Guttridge, Sawsan Khuri, Leonidas G. Koniaris et al. STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia PLoS ONE 7/20/2011 [PMID: 21799891]
Tsuyoshi Chiba, Mary Y. Chang, Shari Wang, Thomas N. Wight, Timothy S. McMillen, John F. Oram et al. Serum Amyloid A Facilitates the Binding of High-Density Lipoprotein From Mice Injected With Lipopolysaccharide to Vascular Proteoglycans Arteriosclerosis, Thrombosis, and Vascular Biology 6/1/2011 [PMID: 21474830]
Malik P, Berisha SZ, Santore J Zymosan-mediated inflammation impairs in vivo reverse cholesterol transport. J. Lipid Res., 2011-02-19;52(5):951-7. 2011-02-19 [PMID: 21335620] (Western Blot, Mouse)	Western Blot	Mouse
Tasaki M, Ueda M, Ochiai S, Tanabe Y, Murata S, Misumi Y, Su Y, Sun X, Shinriki S, Jono H, Shono M, Obayashi K, Ando Y Transmission of circulating cell-free AA amyloid oligomers in exosomes vectors via a prion-like mechanism. Biochem. Biophys. Res. Commun., 2010-08-31;400(4):559-62. 2010-08-31 [PMID: 20807507] (Western Blot, Mouse)	Western Blot	Mouse
Saraswathi V, Gao L, Morrow JD, Chait A, Niswender KD, Hasty AH Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. J. Nutr., 2007-07-01;137(7):1776-82. 2007-07-01 [PMID: 17585030] (ELISA Development, Mouse)	ELISA Development	Mouse
Zlobec I, Lugli A, Baker K, Roth S, Minoo P, Hayashi S, Terracciano L, Jass JR Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer. J. Pathol., 2007-07-01;212(3):260-8. 2007-07-01 [PMID: 17516584] (ELISA Development, Mouse)	ELISA Development	Mouse
Show All 37 Publications. Collapse Publications.

Array AF2948

• Serum Amyloid A1/A2 Antibodies
• Serum Amyloid A1/A2 ELISA Kits