Western Blot: Septin-4 Antibody [NBP1-90094] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). ...read more
Orthogonal Strategies: Immunohistochemistry-Paraffin: Septin-4 Antibody [NBP1-90094] - Staining in human cerebral cortex and pancreas tissues using anti-SEPT4 antibody. Corresponding SEPT4 RNA-seq data are ...read more
Immunohistochemistry-Paraffin: Septin-4 Antibody [NBP1-90094] - Staining of human cerebellum shows moderate cytoplasmic positivity in cells in granular layer and distinctly stained neuropil.
Immunohistochemistry-Paraffin: Septin-4 Antibody [NBP1-90094] - Staining of human cerebral cortex shows high expression.
Immunohistochemistry-Paraffin: Septin-4 Antibody [NBP1-90094] - Staining of human pancreas shows low expression as expected.
This antibody was developed against Recombinant Protein corresponding to amino acids: YDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKS
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SEPTIN4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%), Rat (84%)
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Septin-4 Antibody
Apoptosis-related protein in the TGF-beta signaling pathway
ARTSPeanut-like protein 2
Bradeion beta
BRADEION
Brain protein H5
CE5B3
Cell division control-related protein 2
Cerebral protein 7
H5
hCDCREL-2SEP4
hucep-7
MART
peanut-like 2 (Drosophila)
peanut-like 2
PNUTL2CE5B3 beta
septin 4
septin-4
septin-M
Background
Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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