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SDPR Antibody

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Western blot shows lysates of human heart and mouse lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse SDPR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5759) followed by ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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SDPR Antibody Summary

Immunogen
E. coli-derived recombinant human SDPR
Gly2-Val180
Accession # O95810
Specificity
Detects human and mouse SDPR in Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SDPR
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
AF5759 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SDPR Antibody

  • cavin-2
  • Phosphatidylserine-binding protein
  • PS-p68
  • PS-p68serum deprivation response (phosphatidylserine-binding protein)
  • SDPR
  • SDR
  • SDRphosphatidylserine binding protein
  • serum deprivation response (phosphatidylserine binding protein)
  • serum deprivation response
  • serum deprivation-response protein

Background

SDPR (Serum deprivation response gene; also SDR and PS-p68) is a 68‑70 kDa member of the PTRF/SDPR family of proteins. It is expressed in striated muscle, platelets, and fibroblasts, and is cytosolic in location. SDPR is known to bind phosphatidylserine and form complexes with both PKC alpha and PTRF, targeting them to caveolae. Human SDPR is 425 amino acids (aa) in length. It contains an N-terminal acetylglycine, three coiled-coil regions (aa 61‑82, 125‑154, and 210‑268), and two serine phosphorylation sites at positions 287 and 293. Over aa 1‑180, human SDPR shares 91% aa identity with mouse SDPR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SDPR Antibody (AF5759)(6)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.


Filter By Application
Western Blot
(2)
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Human
(1)
Mouse
(1)
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Showing Publications 1 - 6 of 6.
Publications using AF5759 Applications Species
Maider Varela-Guruceaga, Elise Belaidi, Lucie Lebeau, Ella Aka, Ramaroson Andriantsitohaina, Sophie Giorgetti-Peraldi et al. Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance Development Frontiers in Physiology 11/26/2020 [PMID: 33324235]
E Seemann, M Sun, S Krueger, J Tröger, W Hou, N Haag, S Schüler, M Westermann, CA Huebner, B Romeike, MM Kessels, B Qualmann Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination Elife, 2017-12-05;6(0):. 2017-12-05 [PMID: 29202928] (Western Blot, Mouse) Western Blot Mouse
Krzysztof M. Krawczyk, Jennifer Hansson, Helén Nilsson, Katarzyna K. Krawczyk, Karl Swärd, Martin E. Johansson Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1 BMC Nephrology 12/1/2017 [PMID: 29065889]
B Hansson, C Rippe, D Kotowska, S Wasserstro, J Säll, O Göransson, K Swärd, KG Stenkula Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBP?-dependent manner PLoS ONE, 2017-03-09;12(3):e0173412. 2017-03-09 [PMID: 28278164] (Western Blot, Human) Western Blot Human
Alexander Ludwig, Gillian Howard, Carolina Mendoza-Topaz, Thomas Deerinck, Mason Mackey, Sara Sandin et al. Molecular Composition and Ultrastructure of the Caveolar Coat Complex PLoS Biology 8/27/2013 [PMID: 24013648]
Mardjaneh Sadegh Karbalaei, Catarina Rippe, Sebastian Albinsson, Mari Ekman, Alva Mansten, Bengt Uvelius et al. Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice European Journal of Pharmacology 8/15/2012 [PMID: 22643325]

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Bioinformatics

Gene Symbol SDPR
Uniprot