| Reactivity | Hu, Mu, RtSpecies Glossary |
| Applications | Flow, ICC/IF, IHC, CyTOF-ready, ICC/IF |
| Clone | 47-8D3 (DF3973) |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugate | DyLight 405 |
| Description | This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet. |
| Immunogen | Human peripheral blood monocyte components (Uniprot: P06702) |
| Localization | Cytoplasmic, Extracellular (secreted) and Cell Surface |
| Marker | Macrophage Marker |
| Specificity | This monoclonal antibody stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffers cells of the skin. It also stains the mantle zone B-lymphocytes of the lymph node and spleen, spermatogonia, and chief cells of the stomach. S100A9 is expressed by macrophages in acutely inflamed tissues and in chronic inflammation. It is detected in peripheral blood leukocytes, in neutrophils and granulocytes. It is present at sites of vascular inflammation. S100A9 is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a Calcium-binding protein. It has antimicrobial activity towards bacteria and fungi. It is important for resistance to invasion by pathogenic bacteria. It up-regulates transcription of genes that are under the control of NF-kappa-B. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. It plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. |
| Isotype | IgG1 Kappa |
| Clonality | Monoclonal |
| Host | Mouse |
| Gene | S100A9 |
| Purity | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Application Notes | Optimal dilution of this antibody should be experimentally determined. |
| Storage | Store at 4C in the dark. |
| Buffer | 50mM Sodium Borate |
| Preservative | 0.05% Sodium Azide |
| Purity | Protein A or G purified |
![S100A9 Antibody (47-8D3 (DF3973)) [DyLight 405]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "S100A9 Antibody (47-8D3 (DF3973)) [DyLight 405]")
Secondary Antibodies |
Isotype Controls |
Research Areas for S100A9 Antibody (NBP2-47980V)Find related products by research area.
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| Gene Symbol | S100A9 |
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