Ryk Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

RYK (related to tyrosine (Y) kinase; also H-RYK) is a 70-90 kDa, atypical member of the tyrosine protein kinase family. It is a type I transmembrane glycoprotein that binds Wnt, and forms a Wnt receptor complex with frizzled. In this capacity, it serves as a link between Wnt and Dishevelled. Human RYK is 604 amino acids (aa) in length (SwissProt Accession # P34925). It contains a 25 aa signal sequence and a 199 aa extracellular region (aa 26-224) that shows one WIF-1-like domain (aa 63‑191). The cytoplasmic region possesses a nonfunctional Ser/Thr protein kinase domain (aa 327-600). One isoform exists that shows a 31 aa substitution between aa’s 18-46. Over aa 47-224, human RYK is 94% aa identical to mouse RYK.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using AF4907	Applications	Species
YH Lee, MM Lee, DM De Silva, A Roy, CE Wright, TK Wong, R Costello, O Olaku, RL Grubb, PK Agarwal, AB Apolo, DP Bottaro Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder PLoS ONE, 2021-07-22;16(7):e0241766. 2021-07-22 [PMID: 34292953]
Tianzhi Huang, Angel A. Alvarez, Rajendra P. Pangeni, Craig M M. Horbinski, Songjian Lu, Sung-Hak Kim et al. A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways Nature Communications 2016-10-04 [PMID: 27698350]

Array AF4907

• Ryk Antibodies
• Ryk Lysates
• Ryk Proteins
• Ryk Proteins and Enzymes