RTEL1 Antibody - BSA Free

RTEL1 (Regulator of Telomere Length 1) is a nuclear iron-sulfur cluster containing ATP-dependent DNA helicase essential to genomic stability. RTEL1 contains 1 helicase ATP-binding domain and it belongs to helicase family, RAD3/XPD subfamily. Originally discovered in mouse, RTEL1 is a dominant factor controlling the regulation of telomeric length and genomic integrity, and recent evidence suggest that RTEL1 is preferentially recruited to, or exerts greater activity at genome's G-rich regions. In DNA double-strand breaks (DSBs) repair, RTEL1 disrupts D-loops in vitro and promotes synthesis-dependent strand annealing (SDSA) in vivo to direct DNA DSBs into non-crossover outcomes during mitotic repair. RTEL1 activity is also essential to meiotic recombination regulation as shown in C elegans. RTEL1's multiple roles in genomic stability maintenance and recombination regulation suggests it as a tumor suppressor. Indeed, RTEL1 mutation represents a risk factor for glioma and it is overexpressed in gastrointestinal cancers. Human RTEL1 deficiency caused Hoyeraal-Hreidarsson syndrome (HHS), a severe variant of Dyskeratosis Congenita (DC), characterized by early onset bone marrow failure, immunodeficiency and developmental defects.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: B/N, WB.

Showing Publications 1 - 6 of 6.

Publications using NBP2-22360	Applications	Species
Higa M, Matsuda Y, Fujii J et al. TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress Nucleic Acids Research 2021-12-02 [PMID: 34761263] (WB)	WB
Summers PA, Lewis B, Gonzalez-Garcia J, Lim AHM Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy Nat Commun 2021-01-09 [PMID: 33420085]
Kotsantis P, Segura-Bayona S, Margalef P et al. RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions Cell reports 2020-12-22 [PMID: 33357438] (WB, Mouse)	WB	Mouse
Grzegorz Sarek, Panagiotis Kotsantis, Phil Ruis, David Van Ly, Pol Margalef, Valerie Borel, Xiao-Feng Zheng, Helen R. Flynn, Ambrosius P. Snijders, Dipanjan Chowdhury, Anthony J. Cesare, Simon J. Boulton CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle Nature 2019-10-01 [PMID: 31723267]
Margalef P, Kotsantis P, Borel V et al. Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe. Cell 2017-12-27 [PMID: 29290468] (B/N)	B/N
Chan, YWFugger, KWest, SC Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations Nat. Cell Biol. [PMID: 29255170] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Fernanda gutierrez rodrigues	WB	Human	09/06/2017	View Summary Application Western Blot Sample Tested 293T cell lysate Species Human Lot A062817H Comments Comments Overexpression of RTEL1 in 293T cells

Array NBP2-22360

• RTEL1 Antibodies
• RTEL1 Proteins