TRF-1 Antibody (57-6)

TRF1 (telomeric repeat-binding factor 1) is a protein that binds telomeric double-stranded TTAGGG repeat and is implicated in telomere replication, telomere protection, telomere length maintenance, resolution of sister telomeres and mitotic spindle regulation. TRF1 interacts directly with TIN2 in shelterin complex (TRF1, TRF2, TIN2, POT1, TPP1 and hRap1; a complex that coats telomeres for their protection and regulation of telomere length) and it then binds to TRF2/TPP1. While POT1 binds to TPP1, TRF2 interacts and forms a complex with hRap1. Upon ionizing DNA damage, TRF1 gets phosphorylated (ser-219) in ATM-dependent manner. ADP-ribosylation by TNKS1 or TNKS2 diminishes TRF1's telomeric DNA binding ability, whereas, RLIM/RNF12 as well as SCF (SKP1-CUL1-F-box protein) can ubiquinate TRF1 for its degradation. TRF1 is ubiquitously expressed and during the cell cycle, its levels are low in G1/S phases which may increase during G2/M phases. Overexpression of TRF1 promotes telomere shortening whereas loss of TRF1 accumulate telomere fusions and induce telomerase-dependent telomere lengthening, implying that TRF1 negatively regulates telomerase-dependent telomere extension, perhaps by restricting the access of telomerase to the ends of telomeres. TRF1 knockout leads to embroynic lethality and deletion of TRF1 promotes the formation of fragile telomeres.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 4 applications: Block/Neutralize, ELISA, WB, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using NB110-68281	Applications	Species
Foglio E, D'Avorio E, Vitiello L et al. Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in Mitophagy Cells 2023-11-10 [PMID: 37998340]
Xu Q, Mojiri A, Boulahouache L et al. Vascular senescence in progeria: role of endothelial dysfunction European Heart Journal Open 2022-07-28 [PMID: 36117952] (Western Blot, Block/Neutralize)	Western Blot, Block/Neutralize
Jullien L, Mestre M, Roux P, Gire V. Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response Nucleic Acids Res 2012-11-27 [PMID: 23193277] (WB, Human)	WB	Human
Sharma S, Mukherjee AK, Roy SS et al. Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2 bioRxiv 2020-01-01
Sharma S, Mukherjee AK, Roy SS et al. Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction Cell reports 2021-05-18 [PMID: 34010660] (ELISA, Human)	ELISA	Human
Chen YL, Sheu JJ, Sun CK et al. MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis Mol. Med. 2020-05-14 [PMID: 32410577] (WB, Rat)	WB	Rat

Array NB110-68281

• TRF-1 Antibodies
• TRF-1 ELISA Kits
• TRF-1 Lysate
• TRF-1 Proteins